Meningoencephalopathy as a clinical manifestation of Epstein–Barr virus‐associated hemophagocytic syndrome
Meningoencephalopathy as a clinical manifestation of Epstein–Barr virus‐associated hemophagocytic syndrome
复制标题
脑膜脑病是 Epstein-Barr 病毒相关噬血细胞综合征的临床表现
DOI：
10.1002/ncn3.19
复制
发表时间：
2013
影响因子：
0.4
通讯作者：
N. Suzuki
中科院分区：
文献类型：
--
作者：
K. Koizumi;Y. Tsukada;D. Ito;S. Momoshima;S. Okamoto;N. Suzuki
A 17‐year‐old Japanese woman with refractory Epstein–Barr virus‐associated hemophagocytic syndrome (EB‐VAHS) developed meningoencephalopathy with seizures. A magnetic resonance imaging (MRI) examination showed multiple lesions with gadolinium enhancement in the cortex of the hemisphere, hypothalamus and brainstem. In addition, contrast‐enhanced fluid‐attenuated inversion recovery (FLAIR) images showed the abnormal enhancement of the leptomeninges. A cerebrospinal fluid analysis detected Epstein–Barr virus polymerase chain reaction positivity, the absence of pleocytosis and an increased protein level. Prompt initiation of high‐dose steroid therapy dramatically improved the symptoms and abnormal MRI findings. This case suggests that contrast‐enhanced FLAIR images and Epstein–Barr virus polymerase chain reaction using a cerebrospinal fluid sample might be useful for the early detection of central nervous system involvement in VAHS.
