Serum HE4 Level is an Independent Prognostic Factor in Epithelial Ovarian Cancer
Serum HE4 Level is an Independent Prognostic Factor in Epithelial Ovarian Cancer
复制标题
DOI：
10.1245/s10434-011-1943-5
复制
发表时间：
2012-05-01
影响因子：
3.7
通讯作者：
Kang, Sokbom
中科院分区：
文献类型：
--
作者：
Kong, Sun-Young;Han, Mi Hwa;Kang, Sokbom
本研究旨在确定血清HE 4是否是卵巢癌患者的独立预后因素，我们采用酶联免疫吸附测定法检测了80例卵巢上皮性癌患者治疗前血清样本中的HE 4。卵巢癌患者血清HE_4水平中位数为98.7（80.3-222.8）pg/ml。治疗前血清HE 4水平升高与无进展生存率降低显著相关（对数秩检验，P = 0.017）。多因素分析显示血清HE 4是无进展生存期的独立预后因素（P = 0.036）。多元回归分析显示，高血清HE 4水平与高肿瘤分级和浆液性组织学显著相关（P = 0.004和0.017）。此外，高水平的血清HE 4水平与残余肿瘤大小和手术时间显著相关（P = 0.003和0.033），治疗前血清HE 4水平可能是预测卵巢上皮性癌患者预后的一个额外因素。由于其独立于既定的预后因素，血清HE 4可能提供额外的预后信息。
This study was designed to determine whether serum HE4 is an independent prognostic factor in ovarian cancer patients.We measured HE4 in pretreatment serum samples from 80 women with epithelial ovarian cancer, using an enzyme-linked immunosorbent assay. The results were correlated with clinical data.The median serum HE4 level in ovarian cancer patients was 98.7 (range, 80.3-222.8) pg/ml. Elevated serum HE4 levels before therapy significantly correlated with a poorer progression free survival (log-rank test, P = 0.017). Multivariate analysis revealed serum HE4 to be an independent prognostic factor for progression-free survival (P = 0.036). In multivariate regression analysis, high serum HE4 levels significantly correlated with high tumor grade and serous histology (P = 0.004 and 0.017). In addition, high serum HE4 levels were significantly associated with residual tumor size and operative time (P = 0.003 and 0.033).Pretreatment serum HE4 seems to be an additional factor for predicting the outcome of patients with epithelial ovarian cancer. Due to its independence from established prognostic factors, serum HE4 may provide additional prognostic information.