Coronin 1 Is Essential for IgM-Mediated Ca2+ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo
Coronin 1 Is Essential for IgM-Mediated Ca2+ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo
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DOI：
10.4049/jimmunol.0801811
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发表时间：
2009-02-15
影响因子：
4.4
通讯作者：
Pieters, Jean
中科院分区：
文献类型：
--
作者：
Combaluzier, Benoit;Mueller, Philipp;Pieters, Jean
冠状蛋白1是一种白细胞特异性的钙依赖性信号调节剂，对外周血T淋巴细胞的存活至关重要，但其在B细胞中的作用尚不清楚。在这项研究中，我们表明，冠状蛋白1是必不可少的细胞内Ca 2+动员和增殖后触发的BCR。然而，共刺激信号的存在使得冠状蛋白1抑制B细胞信号传导，这与冠状蛋白1缺陷小鼠中针对各种Ag的正常免疫应答的产生一致。我们的结论是冠蛋白1，而T细胞的功能和生存是必不可少的，是在体内的B细胞功能。免疫学杂志，2009，182：1954-1961。
Coronin 1 is a leukocyte specific regulator of Ca2+-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca2+ mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo. The Journal of Immunology, 2009, 182: 1954-1961.