Establishing the inter-rater reliability of spinal cord damage manual measurement using magnetic resonance imaging
Establishing the inter-rater reliability of spinal cord damage manual measurement using magnetic resonance imaging
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DOI：
10.1038/s41394-019-0164-1
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发表时间：
2019-02-18
影响因子：
1.2
通讯作者：
Smith, Andrew C.
中科院分区：
文献类型：
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作者：
Cummins, David P.;Connor, Jordan R.;Smith, Andrew C.
研究设计：回顾性研究。目的探讨磁共振成像（MRI）定量评价颈段不完全性脊髓损伤（SCI）后脊髓损伤程度的信度。MRI用于手动测量10名颈椎不完全性SCI受试者的头部和尾部水肿边界、水肿长度、正中矢状组织桥比率、轴向损伤比率和水肿体积。设置学术性大学设置。方法收集10例SCI患者的结构MRI资料，来自西北大学神经肌肉成像与研究实验室。所有手动测量均使用OsiriX（Pixmeo Sarl，日内瓦，瑞士）进行。组内相关系数（ICC）被用来确定跨7个不同经验的评分员之间的评分员的可靠性。结果所有测量指标的评分者间信度均为高至优。头/尾受累水平、水肿长度、中矢状组织桥比率、轴向损伤比率和水肿体积的ICC值分别为0.99、0.98、0.90、0.84和0.93。结论人工MRI测量脊髓损伤在评分者之间是可靠的。研究人员和临床医生可以自信地利用手动MRI测量来量化脊髓损伤。未来的研究，以预测功能恢复后SCI和更好地通知临床管理是必要的。
Study design Retrospective study. Objectives To establish the inter-rater reliability in the quantitative evaluation of spinal cord damage following cervical incomplete spinal cord injury (SCI) utilizing magnetic resonance imaging (MRI). MRI was used to perform manual measurements of the cranial and caudal boundaries of edema, edema length, midsagittal tissue bridge ratio, axial damage ratio, and edema volume in 10 participants with cervical incomplete SCI. Setting Academic university setting. Methods Structural MRIs of 10 participants with SCI were collected from Northwestern University's Neuromuscular Imaging and Research Lab. All manual measures were performed using OsiriX (Pixmeo Sarl, Geneva, Switzerland). Intraclass correlation coefficients (ICC) were used to determine inter-rater reliability across seven raters of varying experience. Results High-to-excellent inter-rater reliability was found for all measures. ICC values for cranial/caudal levels of involvement, edema length, midsagittal tissue bridge ratio, axial damage ratio, and edema volume were 0.99, 0.98, 0.90, 0.84, and 0.93, respectively. Conclusions Manual MRI measures of spinal cord damage are reliable between raters. Researchers and clinicians may confidently utilize manual MRI measures to quantify cord damage. Future research to predict functional recovery following SCI and better inform clinical management is warranted.