GPR26: A marker for primary glioblastoma?
GPR26: A marker for primary glioblastoma?
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DOI：
10.1016/j.mcp.2007.10.002
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发表时间：
2008-04-01
影响因子：
3.3
通讯作者：
Shervington, Amal A.
中科院分区：
文献类型：
--
作者：
Carter, Alan N.;Cole, Clare L.;Shervington, Amal A.
胶质母细胞瘤是高度恶性的脑部肿瘤；它们被描述为最致命的人类癌症之一。该疾病存在两种概念分类：原发性（新发），无既往疾病表现；继发性胶质母细胞瘤，由先前存在的胶质瘤发展而来。本研究旨在调查GPR26在不同年龄患者的胶质母细胞瘤组织中是否存在差异转录，以确定一个候选基因标记。利用聚合酶链反应（PCR）比较了9个样本（7个胶质母细胞瘤组织和2个正常脑组织）中GPR26的转录情况。尽管GPR26存在于胶质母细胞瘤组织中，但在测试的4个细胞系中均未转录。比较了正常样本和癌性样本以及年龄类别（<60岁和≥60岁）之间的GPR26转录比率。结果表明GPR26存在差异转录，在老年患者组织中的转录显著减少，p值为0.03暗示了这一点。本研究已确定GPR26是原发性胶质母细胞瘤的一个基因指标，表明它可能是原发性胶质母细胞瘤发展的抑制因子。（C）2007爱思唯尔有限公司。保留所有权利。
Glioblastomas are highly malignant brain tumours; they have been described as one of the most deadly human cancers. Two conceptual classifications of the condition exist: primary (de novo), which does not exhibit prior disease and secondary glioblastoma, which develops from a pre-existing glioma. This study investigates whether GPR26 is differentially transcribed in glioblastoma tissue from patients of different ages, in order to de. ne a candidate genetic marker. The transcriptional pro. le of GPR26 was compared in nine samples: seven glioblastoma tissues and two normal brain tissues using PCR. Despite GPR26 being present in the glioblastoma tissues, it was not transcribed in any of the four cell lines tested. GPR26 transcription ratios were compared between normal and cancerous samples, also age categories 60 years were compared. Results suggested differential transcription of GPR26, which is significantly less transcribed in tissues from older patients, implied by a p-value of 0.03. This study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development. (C) 2007 Elsevier Ltd. All rights reserved.