A three‐allele model for heterogeneity of juvenile onset insulin‐dependent diabetes
A three‐allele model for heterogeneity of juvenile onset insulin‐dependent diabetes
复制标题
青少年胰岛素依赖型糖尿病异质性的三等位基因模型
DOI：
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发表时间：
1980
影响因子：
1.9
通讯作者：
K. L. Lange
中科院分区：
文献类型：
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作者：
S. Hodge;J. Rotter;K. L. Lange
一个三等位基因模型提出了“青少年”胰岛素依赖型糖尿病（IDDJI）的遗传。该模型假设易感基因座S与HLA复合体紧密连锁。该模型结合了文献中的相对风险和HLA相关性数据，这些数据表明了IDDM的遗传异质性，以及人群患病率，双胞胎和同胞一致率，以及受影响同胞对HLA单倍型一致性值的扭曲。该模型似乎对现有数据提供了合理的拟合。它预测了一些，但不是所有的基因型和HLA B8和一个S等位基因之间的强关联的低等位基因。该模型对不同形式的IDDX在散发性和家族性病例中的分布进行了额外的具体预测。这些预测可以在未来的遗传流行病学研究中进行测试。
A three‐allele model is presented for the inheritance of ‘juvenile’ insulin‐dependent diabetes mellitus (IDDJI). The model postulates a susceptibility locus S tightly linked to the HLA complex. The model incorporates relative‐risk and HLA‐association data from the literature which suggest genetic heterogeneity within IDDM, together with population prevalence, twin and sib concordance rates, and distortions in HLA haplotype concordance values for affected sib pairs. The model appears to provide a reasonable fit to existing data. It predicts low penetrances for some, but not all, genotypes and a strong association between HLA B8 and one of the S alleles. The model makes additional specific predictions about how different forms of IDDX are distributed in sporadic and familial cases. These predictions can be tested in future genetic‐epidemiologic studies.