ASSOCIATION ANALYSIS OF A POLYMORPHISM OF THE ANGIOTENSIN CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN THE JAPANESE POPULATION
ASSOCIATION ANALYSIS OF A POLYMORPHISM OF THE ANGIOTENSIN CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN THE JAPANESE POPULATION
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DOI：
10.1006/bbrc.1993.1231
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发表时间：
1993-03-15
影响因子：
3.1
通讯作者：
OGIHARA, T
中科院分区：
文献类型：
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作者：
HIGASHIMORI, K;ZHAO, Y;OGIHARA, T
在日本人群中进行了ACE基因内含子16插入/缺失（I/D）多态性与原发性高血压的关联研究。聚合酶链反应检测287 bp的I/D多态性。133例高血压患者和104例血压正常者的插入和缺失等位基因频率无显著差异。I/D多态性与血浆ACE活性在正常血压组中有显著相关性，但在高血压组中无相关性。这些结果表明，I/D多态性的基因是没有牵连的日本高血压受试者，涉及不同种族的研究是很重要的。
An association study of the insertion/deletion (I/D) polymorphism located in intron 16 of the ACE gene with essential hypertension in the Japanese population was performed. The 287 bp I/D polymorphism was detected by polymerase chain reaction. Derived allele frequencies for insertion and deletion were not significantly different between 133 hypertensive and 104 normotensive subjects. A significant relationship between I/D polymorphism and plasma ACE activity was observed in the normotensive group, but not in hypertensives. These results suggest that I/D polymorphism of the gene is not implicated in Japanese hypertensive subjects, and that studies involving various ethnic groups are important.