Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: Results from the FINBAR study
Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: Results from the FINBAR study
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DOI：
10.3748/wjg.v13.i10.1585
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发表时间：
2007-03-14
影响因子：
4.3
通讯作者：
Murray, Liam J.
中科院分区：
文献类型：
--
作者：
Anderson, Lesley A.;Watson, R. G. Peter;Murray, Liam J.
目的：调查与 Barrett 食管和食管腺癌相关的危险因素。方法：这项基于全爱尔兰人群的病例对照研究招募了 224 名 Barrett 食管患者、227 名食管腺癌患者和 260 名对照者。所有参与者都接受了结构化访谈，获取有关潜在生活方式和环境危险因素的信息。 结果：胃食管反流与 Barrett 病 [OR 12.0 (95% CI 7.64-18.7)] 和食管腺癌 [OR 3.48 (95% CI 2.25-5.41)] 相关。与对照组相比，食管腺癌患者更有可能是前吸烟者或当前吸烟者[分别为 OR 1.72 (95% CI 1.06-2.81) 和 OR 4.84 (95% CI 2.72-8.61)]，并且体重指数较高 [OR 2.69 (95% CI 1.62-4.46)]。未观察到这些危险因素与巴雷特食管之间存在显着关联。水果而非蔬菜与食管腺癌呈负相关[OR 0.50 (95% CI 0.30-0.86)]。结论：高体重指数、低水果饮食和吸烟可能与巴雷特食管向食管腺癌的进展有关。 (c) 2007 年 WIG 出版社。版权所有。
AIM: To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS: This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinorna patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS: Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinorna [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinorna patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinorna [OR 0.50 (95% CI 0.30-0.86)].CONCLUSION: A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinorna. (c) 2007 The WIG Press. All rights reserved.