Antibacterial Drug Shortages From 2001 to 2013: Implications for Clinical Practice
Antibacterial Drug Shortages From 2001 to 2013: Implications for Clinical Practice
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DOI：
10.1093/cid/civ201
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发表时间：
2015-06-15
影响因子：
11.8
通讯作者：
May, Larissa
中科院分区：
文献类型：
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作者：
Quadri, Farha;Mazer-Amirshahi, Maryann;May, Larissa
背景以前的研究已经描述了药物短缺，但是，一直没有全面的评价集中在美国抗菌药物短缺。分析了来自犹他州大学药物信息服务数据库的药物短缺数据，重点是2001年至2013年的抗菌药物。我们使用描述性统计来描述药物短缺的趋势，分析通常受影响的药物类别，并调查药物是否经历了多个短缺期。在13年的研究期间，有148种抗菌药物短缺，截至2013年12月，仍有26种药物短缺。每年新短缺的中位数为10（四分位距[IQR]，7）。从2007年7月到2013年12月，短缺药物数量以每月0.35种药物的速度增加（95%置信区间，.22-.49）（P < .001）。短缺持续时间的中位数为188天（IQR，366.5）。22%的药物经历了多个短缺期。2001年至2013年期间，出现了大量药品短缺，自2007年以来短缺情况急剧上升。由于持续传播和有限的治疗选择，用于治疗耐多药感染的药物短缺令人关切。
Background. Previous studies have described drug shortages; however, there has been no comprehensive evaluation focusing on US antibacterial shortages.Methods. Drug shortage data from the University of Utah Drug Information Service database were analyzed, with a focus on antibacterial agents from 2001 to 2013. We used descriptive statistics to describe trends in drug shortages, analyze drug classes commonly affected, and investigate whether drugs experienced multiple periods of shortages.Results. One hundred forty-eight antibacterial drugs were on shortage over the 13-year study period, with 26 drugs still active on shortage as of December 2013. The median number of new shortages per year was 10 (interquartile range [IQR], 7). The number of drugs on shortage increased at a rate of 0.35 additional drugs every month (95% confidence interval,.22-.49) from July 2007 to December 2013 (P < .001). The median shortage duration was 188 days (IQR, 366.5). Twenty-two percent of drugs experienced multiple shortage periods.Conclusions. There were a substantial number of drug shortages from 2001 to 2013, with a dramatic rise in shortages since 2007. Shortages of agents used to treat multidrug-resistant infections are of concern due to continued transmission and limited treatment options.