"Wax-Sealed" Theranostic Nanoplatform for Enhanced Afterglow Imaging-Guided Photothermally Triggered Photodynamic Therapy
"Wax-Sealed" Theranostic Nanoplatform for Enhanced Afterglow Imaging-Guided Photothermally Triggered Photodynamic Therapy
复制标题
用于增强余辉成像引导光热触发光动力治疗的“蜡封”治疗诊断纳米平台
DOI：
10.1002/adfm.201804317
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发表时间：
2018-10-17
影响因子：
19
通讯作者：
Dong, Xiaochen
中科院分区：
文献类型：
--
作者：
Liu, Gongyuan;Zhang, Shichao;Dong, Xiaochen
在此，持续发光纳米颗粒（PLNP）和光敏剂被整合用于具有高特异性且不需要连续照明的癌症治疗诊断。具体地，ZnGa1.996O4：Cr-0.004（PLNP）和IR 780（光敏剂）被由油酸和十六醇组成的温度响应性“蜡封”封装。密封防止发光猝灭和光动力治疗（PDT）的过早启动，直到它被热刺激熔化。在光热活化后，由PLNP提供的近红外余辉提供了具有高信号背景比的成像，因为不存在组织自体荧光，以及用于活性氧物质产生的连续激发的光敏剂。这种治疗诊断纳米平台提供了多模态成像引导的局部癌症PDT。
Herein, persistent luminescence nanoparticles (PLNPs) and photosensitizer are integrated for cancer theranostics with high specificity and without the need of continuous illumination. Specifically, ZnGa1.996O4:Cr-0.004 (PLNPs) and IR780 (photosensitizer) are encapsulated by a temperature-responsive "wax-seal" composed of oleic acid and hexadecanol. The seal prevents luminescence quenching and premature initiation of photodynamic therapy (PDT), until it is melted down by heat stimulus. After photothermal activation, the near-infrared afterglow offered by PLNPs provides imaging with high signal-to-background ratio because of the absence of tissue autofluorescence, as well as continuously excited photosensitizer for reactive oxygen species generation. Such theranostic nanoplatform offers multimodal imaging-guided localized cancer PDT.