Persistent postsurgical pain in a general population: Prevalence and predictors in the Tromso study
Persistent postsurgical pain in a general population: Prevalence and predictors in the Tromso study
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DOI：
10.1016/j.pain.2012.02.018
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发表时间：
2012-07-01
期刊：
影响因子：
7.4
通讯作者：
Stubhaug, Audun
中科院分区：
文献类型：
--
作者：
Johansen, Aslak;Romundstad, Luis;Stubhaug, Audun
关于持续性术后疼痛患病率的基于人群的数据很稀缺。本研究旨在评估一般人群中持续性术后疼痛的患病率，并描述相关的生理、社会和心理因素，包括神经损伤和敏感化的症状。在挪威北部进行了一项横断面调查，调查问卷的项目涵盖手术、疼痛以及手术区域的感觉异常。在12982名参与者中，24.0%（3111人）在调查前的3年期间接受过一次或多次手术。其中，2043人是在调查前3个月以上做的手术。40.4%的患者（2043人中的826人）报告手术区域有持续性疼痛，18.3%（2043人中的373人）报告有中度或重度疼痛。24.5%（2043人中的501人）报告有感觉减退、感觉过敏或两者皆有。感觉异常和持续性疼痛之间有很强的关联，且随着疼痛强度的增加而增强；感觉减退的优势比为2.68，感觉过敏的优势比为6.27。在826名报告手术解剖区域有持续性疼痛的个体中，当在不特别提及手术的情况下询问时，51.0%报告有慢性疼痛。本研究支持来自持续性术后疼痛临床研究的证据，表明其患病率较高，但显示出在疼痛报告方面存在很大差异，这取决于所问的问题以及提问的背景。感觉异常和疼痛之间的强关联表明在大部分病例中存在神经病理性机制。（C）2012国际疼痛研究协会。由爱思唯尔出版集团出版。保留所有权利。
Population-based data on the prevalence of persistent postsurgical pain are scarce. This study aimed to assess the prevalence of persistent postsurgical pain in a general population and to describe associated physical, social, and psychological factors, including symptoms of nerve injury and sensitization. A cross-sectional survey was performed in northern Norway with questionnaire items covering surgery, pain, and sensory abnormalities in the area of surgery. Of the 12,982 participants, 24.0% (3111) had undergone one or more surgical procedures during the 3 years preceding the survey. Of these, 2043 had the surgery performed more than 3 months before the investigation. Persistent pain in the area of surgery was reported by 40.4% of the patients (826 of 2043), moderate or severe pain by 18.3% (373 of 2043). Hypoesthesia, hyperesthesia, or both was reported by 24.5% (501 of 2043). There were strong associations between sensory abnormalities and persistent pain, increasingly with higher pain intensities; odds ratios were 2.68 for hypoesthesia and 6.27 for hyperesthesia. Of the 826 individuals reporting persistent pain in the anatomical area of surgery, 51.0% reported chronic pain when questioned without specific reference to the surgery. The present study supports evidence from clinical studies of persistent postsurgical pain, indicating a high prevalence, but reveals large discrepancies in report of pain, depending on the questions asked and the context in which the questions are presented. Strong associations between sensory abnormalities and pain indicate neuropathic mechanisms in a major proportion of cases. (C) 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.