Five cases of measles secondary vaccine failure with confirmed seroconversion after live measles vaccination
Five cases of measles secondary vaccine failure with confirmed seroconversion after live measles vaccination
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DOI：
10.3109/00365549709035882
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发表时间：
1997-01-01
影响因子：
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通讯作者：
Yoshikawa, H
中科院分区：
文献类型：
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作者：
Hirose, M;Hidaka, Y;Yoshikawa, H
我们报告了5例二次疫苗失败（SVF）患者，他们分别在婴儿期接种麻疹减毒活疫苗后2、5、5、7和12年感染了自然麻疹。他们的血清转化在接种疫苗后得到证实。5例患者中3例为轻度（改良）麻疹，其余2例为典型麻疹。4/5患者急性期和恢复期配对血清中麻疹病毒血凝抑制抗体滴度为二次应答，其余患者为一次应答。所有患者在恢复期均存在麻疹IgM抗体。具有原发性应答模式的患者可能在接种疫苗和感染之间的5年期间B细胞记忆下降。这可能是第一个证实进一步减毒麻疹活疫苗接种者存在免疫力完全下降的SVF病例报告。
We report 5 patients with secondary vaccine failure (SVF) who were infected with natural measles 2, 5, 5, 7 and 12 years, respectively, after vaccination with further attenuated live measles vaccine during infancy. Their seroconversion had been confirmed after vaccination. Three of the 5 patients had mild (modified) measles, while the remaining 2 patients had typical measles. The hemagglutination inhibition antibody titers to measles virus in paired acute and convalescent sera showed a secondary response pattern in 4/5 patients, and a primary response pattern was present in the remaining patient. Measles IgM antibodies were present in all patients during the convalescent stage. The patient with the primary response pattern may hare had a decrease in the B cell memory during the 5-year period between vaccination and infection. This may be the first SVF case report that confirms the existence of completely waning immunity in recipients of the further attenuated live measles vaccines.