Reproductive and Hormonal Factors Associated with Fatty or Dense Breast Patterns among Korean Women
Reproductive and Hormonal Factors Associated with Fatty or Dense Breast Patterns among Korean Women
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DOI：
10.4143/crt.2011.43.1.42
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发表时间：
2011-03-01
影响因子：
4.6
通讯作者：
Park, Eun-Cheol
中科院分区：
文献类型：
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作者：
Jeon, Jei-Hun;Kang, Jung-Hyun;Park, Eun-Cheol
目的致密性乳房被认为是乳腺癌的危险因素，但仍存在争议。本研究评估生殖及荷尔蒙因素与韩国女性致密乳房的关系。材料和方法采用横断面设计，招募了516名妇女，并使用美国放射学院的乳腺成像报告和数据系统（BI-RADS）将乳房密度模式分为脂肪型和致密型。采用单因素和多因素logistic回归模型进行统计分析。结果单因素logistic回归分析显示，年龄越大、体重指数越高、月经初潮年龄越长、口服避孕药使用越早与脂肪性乳房的发生有关。相反，受教育时间较长、饮酒、胎次较低、更年期和使用激素替代疗法与致密乳房有关。调整后，年龄和体重指数与乳腺密度呈负相关（p值分别< 0.01），而未生育和绝经前状态呈正相关。与生育>= 2个孩子的妇女相比，未生育妇女致密性乳房增加11.8倍（趋势p值< 0.01）。与绝经后妇女相比，绝经前妇女致密性乳房增加2.4倍（优势比为2.42；95%可信区间为1.36 ~ 4.32）。结论年轻、低体重指数、低胎次和绝经前状态与韩国致密性乳房有显著相关性。
PurposeDense breasts have been suggested as a risk factor for breast cancer, but controversy still remains. This study evaluates the association of reproductive and hormonal factors with dense breasts among Korean women.Materials and MethodsUsing a cross-sectional design, 516 women were recruited and classified for breast density patterns as being either fatty or dense, using the Breast Imaging Reporting and Data System (BI-RADS) of the American College of Radiology. Univariate and multivariate logistic regression models were used for statistical analysis.ResultsIn univariate logistic regression, older age, higher body mass index, older age at menarche, and oral contraceptive use were associated with more fatty breasts. On the contrary, longer duration of education, alcohol consumption, lower parity, menopause and use of hormone replacement therapy were associated with dense breasts. After adjustment, age and body mass index were inversely associated with breast density (p-value for trend < 0.01, respectively), whereas nulliparous and premenopausal status were positively associated. Compared to women who had >= 2 children, nulliparous women had an 11.8-fold increase of dense breasts (p-value for trend < 0.01). Compared to postmenopausal women, premenopausal women had 2.4-fold increase of dense breasts (odds ratio, 2.42; 95% confidence interval, 1.36 to 4.32).ConclusionYoung age, lower body mass index, lower parity, and premenopausal status were significantly associated with dense breasts in Korea.