Strain-dependent stress relaxation behavior of healthy right ventricular free wall.
Strain-dependent stress relaxation behavior of healthy right ventricular free wall.
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DOI：
10.1016/j.actbio.2022.08.043
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发表时间：
2022-10-15
影响因子：
9.7
通讯作者：
Wang, Zhijie
中科院分区：
文献类型：
--
作者：
Liu, Wenqiang;Labus, Kevin M.;Ahern, Matt;LeBar, Kristen;Avazmohammadi, Reza;Puttlitz, Christian M.;Wang, Zhijie
关键词：
越来越多的证据表明，在大型动物或人类心肌的应力应变滞后呼吁广泛的表征心肌的被动粘弹性行为。最近的几项研究已经调查和模拟左心室的粘弹性，而右心室（RV）的粘弹性仍然知之甚少。我们的目标是使用两种建模方法来表征RV游离壁（RVFW）的双轴粘弹性行为。我们将准线性粘弹（QLV）和非线性粘弹（NLV）理论应用于健康成年绵羊的实验应力松弛数据。一个三项Prony系列松弛函数结合奥格登应变能密度函数被用于QLV建模，而幂律公式中采用的NLV方法。绵羊RVFW表现出各向异性和应变依赖的粘弹性行为相对于解剖坐标，和NLV模型显示出更高的能力，在预测应变依赖的应力松弛比QLV模型。从QLV拟合，与最大的时间常数相关的松弛项发挥了主导作用，在整体松弛行为在大多数应变从早期到晚期，而与最小的时间常数相关的项是明显的，只有在低应变在早期。从NLV拟合，参数表现出非线性依赖于应变。总的来说，我们的研究的特点是各向异性，非线性粘弹性捕获的弹性和粘性阻力的RVFW在膨胀。这些发现加深了我们对右心室心肌动态力学特性的理解。
The increasing evidence of stress-strain hysteresis in large animal or human myocardium calls for extensive characterizations of the passive viscoelastic behavior of the myocardium. Several recent studies have investigated and modeled the viscoelasticity of the left ventricle while the right ventricle (RV) viscoelasticity remains poorly understood. Our goal was to characterize the biaxial viscoelastic behavior of RV free wall (RVFW) using two modeling approaches. We applied both quasi-linear viscoelastic (QLV) and nonlinear viscoelastic (NLV) theories to experimental stress relaxation data from healthy adult ovine. A three-term Prony series relaxation function combined with an Ogden strain energy density function was used in the QLV modeling, while a power-law formulation was adopted in the NLV approach. The ovine RVFW exhibited an anisotropic and strain-dependent viscoelastic behavior relative to anatomical coordinates, and the NLV model showed a higher capacity in predicting strain-dependent stress relaxation than the QLV model. From the QLV fitting, the relaxation term associated with the largest time constant played the dominant role in the overall relaxation behavior at most strains from early to late diastole, whereas the term associated with the smallest time constant was pronounced only at low strains at early diastole. From the NLV fitting, the parameters showed a nonlinear dependence on the strain. Overall, our study characterized the anisotropic, nonlinear viscoelasticity to capture the elastic and viscous resistances of the RVFW during diastole. These findings deepen our understanding of RV myocardium dynamic mechanical properties.
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DOI：
10.1115/1.4052004
发表时间：
2021-12-01
影响因子：
1.7
作者：
Liu, Wenqiang;Nguyen-Truong, Michael;Wang, Zhijie
通讯作者：
Wang, Zhijie
影响因子：
5.4
作者：
Jang, Sae;Vanderpool, Rebecca R.;Simon, Marc A.
通讯作者：
Simon, Marc A.
DOI：
10.1152/ajpheart.00517.2009
发表时间：
2009-08-01
影响因子：
4.8
作者：
Cooper, George, IV
通讯作者：
Cooper, George, IV
影响因子：
2.4
作者：
HUYGHE, JM;VANCAMPEN, DH;HEETHAAR, RM
通讯作者：
HEETHAAR, RM
影响因子：
5.3
作者：
Labus, Kevin M.;Puttlitz, Christian M.
通讯作者：
Puttlitz, Christian M.