Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks
Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks
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DOI：
10.1073/pnas.0406343101
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发表时间：
2004-10-26
影响因子：
11.1
通讯作者：
Ermentrout, B
中科院分区：
文献类型：
--
作者：
Kopell, N;Ermentrout, B
电突触和化学突触存在于抑制性细胞的同一网络中，并且已知每种突触都能够促进振荡神经元之间的同步性。利用数值和分析技术，我们在此表明，电耦合和抑制性耦合在抑制性网络的节律同步中发挥着不同的作用。所选择的参数范围是由伽马节律所激发的，在伽马节律中，γ - 氨基丁酸A 型（GABA(A)）介导的抑制作用相对较强。在这种条件下，添加一个小的电导率能够比抑制性电导的大幅增加更显著地提高同步程度。抑制性突触的作用是消除不同初始条件的影响，而电突触则减轻由于网络异质性导致的放电抑制。分析技术包括追踪神经元放电峰值之间耦合细胞的轨迹；分析表明，在兴奋性程度存在异质性的网络中，抑制作用会增加放电峰值之间电压的离散度，而电耦合则会降低这种离散度。
Electrical and chemical synapses exist within the same networks of inhibitory cells, and each kind of synapse is known to be able to foster synchrony among oscillating neurons. Using numerical and analytical techniques, we show here that the electrical and inhibitory coupling play different roles in the synchronization of rhythms in inhibitory networks. The parameter range chosen is motivated by gamma rhythms, in which the gamma-aminobutyric acid type A (GABA(A))-mediated inhibition is relatively strong. Under this condition, addition of a small electrical conductance can increase the degree of synchronization far more than a much larger increase in inhibitory conductance. The inhibitory synapses act to eliminate the effects of different initial conditions, whereas the electrical synapses mitigate suppression of firing due to heterogeneity in the network. Analytical techniques include tracking trajectories of coupled cells between spikes; the analysis shows that, in networks in which the degree of excitability is heterogeneous, inhibition can increase the dispersion of the voltages between spikes, whereas electrical coupling reduces such dispersion.