Properties of the cat ileocecal sphincter muscle.
Properties of the cat ileocecal sphincter muscle.
复制标题
猫回盲部括约肌的特性。
DOI：
10.1152/ajpgi.1981.241.3.g222
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Cohen,S
中科院分区：
文献类型：
--
作者：
Cardwell,BA;Rubin,MR;SnapeJr,WJ;Cohen,S
本研究的目的是确定猫回盲部括约肌（ICS）环形平滑肌在体外的长度-张力特性和神经体液剂的反应。ICS肌肉在拉伸过程中保持较高的静息张力在较低程度的拉伸比相邻的回肠和结肠。硝普钠（10（-3）M）或含EGTA（5.0 mM）的无钙Krebs溶液分别使ICS肌肉的静息张力降低15.8 +/- 2.1和19.1 +/-2.5%。ICS对KCl去极化的反应（0.37 ± 0.03 kg/cm 2）低于结肠肌（0.55 ± 0.06 kg/cm 2）或回肠肌（0.51 ± 0.04 kg/cm 2）（P <0.05）。然而，与结肠（0.49 +/-0.05 kg/cm 2）或回肠（0.53 +/-0.05 kg/cm 2）相比，对乙酰胆碱的反应，ICS肌肉张力最小（0.06 +/- 0.02 kg/cm 2）（P <0.01）。ICS肌肉收缩响应苯肾上腺素，而其他肌肉被抑制。促胰液素、胃泌素、胰高血糖素和胆囊收缩素未能作用于ICS肌肉，而其他肌肉确实有反应。这些研究表明，ICS肌肉与邻近的回肠和结肠环形肌肉的不同之处在于：a）响应于拉伸，其产生相对抵抗钙撤回的高静息张力，和B）其还显示响应于神经体液剂的定量和定性差异。
The purpose of this study was to determine the length-tension properties and the response to neurohumoral agents of the feline ileocecal sphincter (ICS) circular smooth muscle in vitro. The ICS muscle during stretch maintained a higher resting tension at lower degrees of stretch than did the adjacent ileum and colon. Sodium nitroprusside (10(-3) M) or calcium-free Krebs solution with EGTA (5.0 mM) reduced the resting tension of ICS muscle by 15.8 +/- 2.1 and 19.1 +/- 2.5%, respectively. The ICS response to KCl depolarization was lower (0.37 +/- 0.03 kg/cm2) than colonic muscle (0.55 +/- 0.06 kg/cm2) oe ileal muscle (0.51 +/- 0.04 kg/cm2) (P less than 0.05). However, in response to acetylcholine, ICS muscle tension was minimal (0.06 +/- 0.02 kg/cm2) was compared with the colon (0.49 +/- 0.05 kg/cm2) or ileum (0.53 +/- 0.05 kg/cm2) (P less than 0.01). The ICS muscle contracted in response to phenylephrine, whereas other muscles were inhibited. Secretin, gastrin, glucagon, and cholecystokinin failed to act on the ICS muscle while other muscles did respond. These studies suggest that ICS muscle differs from adjacent ileal and colonic circular muscle in that a) in response to stretch it develops a high resting tension that is relatively resistant to calcium withdrawal, and b) it also shows quantitative and qualitative differences in response to neurohumoral agents.