Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans
Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans
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DOI：
10.1093/jnci/94.2.108
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发表时间：
2002-01-16
期刊：
影响因子：
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通讯作者：
Jacob, P
中科院分区：
文献类型：
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作者：
Benowitz, NL;Pérez-Stable, EJ;Jacob, P
背景：亚裔和拉丁裔人群的肺癌发病率低于白人。尼古丁代谢的种族差异可能在一定程度上解释了不同种族在香烟消费量和/或每支香烟尼古丁摄入量以及由此产生的烟草相关癌症风险方面的差异。我们比较了不同种族吸烟者的尼古丁代谢率和每支香烟的尼古丁摄入量。
方法：健康的志愿者吸烟者，包括37名华裔美国人、40名拉丁裔和54名白人，同时接受氘标记的尼古丁和可替宁（尼古丁的一种代谢物）的输注。通过血液和尿液检测，确定了尼古丁的处置动力学以及吸烟所致的每日尼古丁摄入量。所有统计检验均为双侧检验。
结果：拉丁裔和白人的尼古丁和可替宁的总清除率及非肾清除率以及通过可替宁途径的尼古丁代谢清除率相似，而华裔美国人的这些指标在统计学上显著较低。华裔美国人每支香烟的尼古丁摄入量（0.73毫克；95%置信区间[CI]=0.53 - 0.94毫克）在统计学上显著低于拉丁裔（1.05毫克；95%CI = 0.85 - 1.25毫克）或白人（1.10毫克；95%CI = 0.91 - 1.30毫克；P = 0.039）。在所有参与者中，尼古丁清除率与吸烟所致的每日尼古丁摄入量以及尼古丁清除率与每支香烟的尼古丁摄入量之间存在统计学上显著的正相关（分别为r = 0.41和r = 0.39）（P<0.001）。这些数据表明，尼古丁代谢率的种族差异可能导致每支香烟尼古丁摄入量的差异，这可能有助于解释不同种族间肺癌发病率的差异。
请注意，最后一行原文中“(P”似乎不完整，如果还有遗漏信息，请补充完整后再次提问。
Background: Lung cancer rates are lower in Asians and Latinos than in whites. Ethnic differences in nicotine metabolism might explain, in part, ethnic differences in cigarette consumption and/or nicotine intake per cigarette and resultant tobacco-related cancer risk. We compared the rate of nicotine metabolism and the intake of nicotine per cigarette smoked among smokers of different ethnicities. Methods: Healthy volunteer smokers, including 37 Chinese-Americans, 40 Latinos, and 54 whites, received simultaneous infusions of deuterium-labeled nicotine and cotinine, a metabolite of nicotine. From blood and urine measurements, the disposition kinetics and daily intake of nicotine from smoking were determined. All statistical tests were two-sided. Results: Total and nonrenal clearance of nicotine and cotinine and metabolic clearance of nicotine via the cotinine pathway were similar in Latinos and whites and statistically significantly lower in Chinese-Americans. Intake of nicotine per cigarette by Chinese-Americans (0.73 mg; 95% confidence interval [CI] = 0.53 to 0.94 mg) was statistically significantly lower than that by Latinos (1.05 mg; 95% CI = 0.85 to 1.25 mg) or whites (1.10 mg; 95% CI = 0.91 to 1.30 mg; P =.039). Among all of the participants, there was a statistically significant positive correlation between nicotine clearance and daily intake of nicotine from cigarette smoking and between nicotine clearance and nicotine intake per cigarette (r =.41 and r =.39, respectively) (P