Protective effects of Punica granatum in experimentally-induced gastric ulcers
Protective effects of Punica granatum in experimentally-induced gastric ulcers
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DOI：
10.3109/15376516.2010.508079
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发表时间：
2010-11-01
影响因子：
3.2
通讯作者：
Jahangir, Tamanna
中科院分区：
文献类型：
--
作者：
Alam, Mohd Sarfaraz;Alam, Mohd Aftab;Jahangir, Tamanna
在本研究中，使用标准化的石榴水甲醇提取物（AMP）对不同实验模型的Wistar大鼠进行溃疡保护活性的研究。AMP的初步植物化学筛选揭示了皂苷，单宁和黄酮类化合物的存在，这可能是负责其活动。AMP的HPTLC指纹图谱显示在不同（保留因子）rf值下存在12个点。口服AMP（490和980毫克/千克体重）显着降低溃疡病变指数产生的酒精，吲哚美辛，阿司匹林，在两个剂量的大鼠。此外，在幽门结扎大鼠AMP显着减少溃疡病变，胃容量和总酸度。它通过增加幽门结扎大鼠的pH和粘液分泌来防止溃疡。本研究显示了AMP在实验诱导的胃溃疡中的抗溃疡活性。
In the present investigation standardized aqueous methanolic extract of Punica (AMP) was used for its possible ulcer protective activity in wistar rats against different experimental models. Preliminary phytochemical screening of AMP reveals the presence of saponin, tannins, and flavonoids, which may be responsible for its activity. HPTLC finger prints of AMP showed the presence of 12 spots at different (retention factor) rf values. Oral administration of AMP (490 and 980 mg/kg bw) significantly reduced the ulcer lesion index produced by alcohol, indomethacin, and aspirin, at both doses in rats. Further, in pylorus-ligated rats AMP significantly reduces the ulcer lesions, gastric volume, and total acidity. It prevents the ulceration by increasing the pH and mucus secretion in pylorus ligated rats. The present study shows the anti-ulcer activity of AMP in experimentally-induced gastric ulcers.