New Insights for Oxidative Stress and Diabetes Mellitus.
New Insights for Oxidative Stress and Diabetes Mellitus.
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DOI：
10.1155/2015/875961
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发表时间：
2015
影响因子：
--
通讯作者：
Maiese K
中科院分区：
文献类型：
--
作者：
Maiese K
活性氧（ROS）的释放和氧化应激的产生被认为是糖尿病（DM）发病机制的关键因素，糖尿病是一种日益流行并导致显著经济损失的疾病。新的治疗方向，解决氧化应激的有害影响，可能特别需要开发有效的护理，目前患有糖尿病的数百万人。雷帕霉素（mTOR）的机制靶点，沉默交配型信息调节2同源物1（S。酿酒酵母）（SIRT 1）和Wnt 1诱导信号通路蛋白1（WISP 1）被认为是DM的治疗靶点，因为这些通路可以解决干细胞、营养因子、葡萄糖耐量受损、细胞凋亡和自噬的程序性细胞死亡通路、组织重塑、细胞能量稳态和血管生物学，极大地影响DM的生物学和疾病进展。将这些途径转化和发展为可行的疗法将需要详细了解其增殖性质，以最大限度地提高临床疗效并限制可能导致意外后果的不良反应。
The release of reactive oxygen species (ROS) and the generation of oxidative stress are considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is growing in prevalence and results in significant economic loss. New therapeutic directions that address the detrimental effects of oxidative stress may be especially warranted to develop effective care for the millions of individuals that currently suffer from DM. The mechanistic target of rapamycin (mTOR), silent mating type information regulation 2 homolog 1 (S. cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are especially justified to be considered treatment targets for DM since these pathways can address the complex relationship between stem cells, trophic factors, impaired glucose tolerance, programmed cell death pathways of apoptosis and autophagy, tissue remodeling, cellular energy homeostasis, and vascular biology that greatly impact the biology and disease progression of DM. The translation and development of these pathways into viable therapies will require detailed understanding of their proliferative nature to maximize clinical efficacy and limit adverse effects that have the potential to lead to unintended consequences.
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影响因子：
7.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1161/01.atv.0000019404.65403.71
发表时间：
2002-06-01
影响因子：
8.7
作者：
Bernal-Mizrachi, C;Weng, S;Semenkovich, CF
通讯作者：
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