Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease
Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease
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DOI：
10.1016/j.neulet.2011.03.087
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发表时间：
2011-06-01
影响因子：
2.5
通讯作者：
Nishimori, Toshikazu
中科院分区：
文献类型：
--
作者：
Ebihara, Kosuke;Ishida, Yasushi;Nishimori, Toshikazu
进行了一项研究，以检查急性和慢性L-DOPA治疗对帕金森病单侧6-羟基多巴胺（6-OHDA）大鼠模型前脑区域中即刻早期基因（IEG）蛋白（FosB、c-Fos和zif 268）分布的影响。在长期L-DOPA治疗（15 mg/天，15天）的过程中，具有6-OHDA损伤的大鼠出现异常的不自主运动。与急性L-DOPA治疗组相比，慢性L-DOPA治疗组大鼠在病变同侧的前扣带回（Cg）和尾壳核背外侧区FosB免疫阳性细胞显著增多，而在病变同侧的Cg、丘脑核壳和杏仁基底外侧核c-Fos免疫阳性细胞显著减少。在急性和慢性L-DOPA组之间没有观察到Zif 268免疫阳性细胞的数量的显著差异。总之，在6-OHDA治疗的偏侧帕金森病大鼠的慢性L-DOPA治疗过程中，在前脑区域中观察到三种IEG蛋白的差异表达。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. During a course of chronic L-DOPA treatment (15 mg/day, 15 days), rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute L-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate (Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion and significantly fewer c-Fos-immunopositive cells in the Cg, the nucleus accumbens shell, and the basolateral nucleus of amygdala ipsilateral to the lesion. No significant difference was observed in the number of Zif268-immunopositive cells between the acute and chronic L-DOPA groups. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats. (C) 2011 Elsevier Ireland Ltd. All rights reserved.