Cerebral palsy after perinatal arterial ischemic stroke
Cerebral palsy after perinatal arterial ischemic stroke
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DOI：
10.1177/0883073807309246
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发表时间：
2008-03-01
影响因子：
1.9
通讯作者：
Williams, Linda S.
中科院分区：
文献类型：
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作者：
Golomb, Meredith R.;Garg, Bhuwan P.;Williams, Linda S.
在围产期动脉卒中数据库中评估儿童脑瘫的频率、残疾程度和残疾的预测因素。在单因素水平上使用Pearson chi(2)和Fisher精确检验评估风险因素，在多因素水平上使用logistic回归分析评估风险因素。围产期中风患儿中有76例（68%）患有脑瘫，最常见的是偏瘫（66/76;87%）。对整个队列的多因素分析显示，延迟出现（OR,9.96; 95% Cl, 3.10-32.02）和男性（OR, 2.55; 95% Cl, 1.03-6.32）与脑瘫相关。在亚组多变量分析中：在有新生儿症状的儿童中，双侧梗死与三肢或四肢瘫痪相关（or, 5.33; 95% Cl, 1.28-22.27）；单侧大脑中动脉梗死患儿，延迟表现（OR, 10.60; 95% Cl, 2.28-72.92）和大分支梗死（OR, 8.78; 95% Cl, 2.18-43.67）与脑瘫相关。这些数据将有助于医生规划围产期中风儿童的长期康复护理。
The frequency of cerebral palsy, degree of disability, and predictors of disability were assessed in children in a perinatal arterial stroke database. Risk factors were assessed at the univariate level using the Pearson chi(2) and Fisher exact test and at the multivariate level using logistic regression analysis. Seventy-six of I I I children with perinatal stroke (68%) had cerebral palsy, most commonly hemiplegic (66/76; 87%). Multivariate analysis of the entire cohort showed both delayed presentation (OR,9.96; 95% Cl, 3.10-32.02) and male sex (OR, 2.55; 95% Cl, 1.03-6.32) were associated with cerebral palsy. In subgroup multivariate analyses: in children with neonatal presentation, bilateral infarcts were associated with triplegia or quadriplegia (OR, 5.33; 95% Cl, 1.28-22.27); in children with unilateral middle cerebral artery infarcts, delayed presentation (OR, 10.60; 95% Cl, 2.28-72.92) and large-branch infarction (OR, 8.78; 95% Cl, 2.18-43.67) were associated with cerebral palsy. These data will aid physicians in planning long-term rehabilitative care for children with perinatal stroke.