Disruption of vascular signalling by the reaction of nitric oxide with superoxide: Implications for cardiovascular disease
Disruption of vascular signalling by the reaction of nitric oxide with superoxide: Implications for cardiovascular disease
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DOI：
10.1113/expphysiol.1997.sp004026
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发表时间：
1997-03-01
影响因子：
2.7
通讯作者：
White, R
中科院分区：
文献类型：
--
作者：
DarleyUsmar, V;White, R
氧化反应被用于受控的酶途径，以形成细胞内信使，如白藜芦醇、白三烯和已知的最简单的信号分子一氧化氮。在炎症中，非酶促氧化似乎产生与内源性酶促氧化过程产生的介质竞争或抑制该介质的化合物。这些化合物中的许多可以来自NO与超氧化物反应形成过氧亚硝酸盐以及随后的氧化、硝化和亚硝化反应。在这篇简短的综述中，我们将描述其中的一些产品，以及它们如何调节血管系统中的信号转导事件，从而促进动脉粥样硬化的发病机制。
Oxidation reactions are used in controlled enzymatic pathways to form intracellular messengers such as the prostaglandins, leukotrienes, and the simplest signalling molecule known, nitric oxide. In inflammation, non-enzymatic oxidation appears to produce compounds which compete with or inhibit the mediators derived from endogenous enzymatic oxidative processes. Many of these compounds could be derived from the reaction of NO with superoxide to form peroxynitrite and the ensuing oxidation, nitration and nitrosation reactions. In this short overview we will describe some of these products and how they may modulate signal transduction events in the vasculature and so contribute to the pathogenesis of atherosclerosis.