Noninvasive Assessment of Tear Stability with the Tear Stability Analysis System in Tear Dysfunction Patients
Noninvasive Assessment of Tear Stability with the Tear Stability Analysis System in Tear Dysfunction Patients
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DOI：
10.1167/iovs.10-5292
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Pflugfelder, Stephen C.
中科院分区：
文献类型：
--
作者：
Gumus, Koray;Crockett, Charlene Hong;Pflugfelder, Stephen C.
目的.采用新型非侵入性泪液稳定性分析系统（TSAS）评价泪液功能障碍患者和无症状对照组的泪膜稳定性。在这项前瞻性病例对照研究中，根据临床严重程度将45例功能障碍性泪液综合征（dysfunctional tear syndrome，简称dRS）患者分为3组（1、2和3/4），评分越高表明症状越严重;对25例无症状对照受试者进行了评价。使用RT-7000自动折射-角膜曲率计（Tomey Corporation，名古屋，日本）进行TSAS测量。捕获并分析每秒投射到角膜上的环形虹膜的图像，持续6秒。亮度的焦点变化被计算为数字环破裂（RBU）值，并且当累积值（RBU总和）超过阈值时经过的时间被定义为环破裂时间（RBUT）。两组的RBUT均显著低于对照组，其中以103/4组的RBUT最低。术后3/4周的RBUT明显短于术后1周（P < 0.001）。在6秒内，两组合并或各组之间RBU总和的变化具有统计学显著性（P < 0.001），1秒和6秒值之间的差异也是如此。对于区分无症状对照组和SLE，5.0秒RBUT临界值的敏感性和特异性分别为82.0%和60.0%。TSAS可能是一个有用的，非侵入性的工具，用于评估撕裂稳定性和分类撕裂的严重程度。（Invest Ophthalmol维斯科学。2011;52：456-461）DOI：10.1167/iovs.10-5292
PURPOSE. To evaluate tear film stability in patients with tear dysfunction and an asymptomatic control group by using the novel, noninvasive Tear Stability Analysis System (TSAS).METHODS. In this prospective case-control study, 45 patients with dysfunctional tear syndrome (DTS) were stratified into three groups (1, 2, and 3/4) based on clinical severity, with higher scores indicating more severe symptoms; 25 asymptomatic control subjects were evaluated. TSAS measurements were performed with the RT-7000 Auto Refractor-Keratometer (Tomey Corporation, Nagoya, Japan). Images of ring mires projected onto the cornea every second for 6 seconds were captured and analyzed. Focal changes in brightness were calculated as numerical ring breakup (RBU) values, and the elapsed time when the cumulative values (RBU sum) exceeded a threshold was defined as the ring breakup time (RBUT).RESULTS. RBUTs in the DTS groups were all significantly lower than those in the control subjects, with the lowest values found in DTS 3/4. RBUT was significantly shorter in DTS 3/4 than in DTS 1 (P < 0.001). The change in RBU sum over a 6-second period in the DTS groups combined or between the individual groups was statistically significant (P < 0.001), as was the difference between the 1-and 6-second values. For distinguishing between asymptomatic controls and DTS, the sensitivity and specificity of a 5.0-second RBUT cutoff were 82.0% and 60.0%, respectively.CONCLUSIONS. The TSAS may be a useful, noninvasive instrument for evaluating tear stability and for classifying DTS severity. (Invest Ophthalmol Vis Sci. 2011;52:456-461) DOI:10.1167/iovs.10-5292