Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma
Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma
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DOI：
10.1016/j.ijom.2021.03.012
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发表时间：
2022-01-07
影响因子：
2.4
通讯作者：
Kumamoto, H.
中科院分区：
文献类型：
--
作者：
Siril, Y. J.;Kouketsu, A.;Kumamoto, H.
细胞周期蛋白D1是细胞周期最重要的进行性调节因子，其转录被CREPT（肿瘤中细胞周期相关和表达升高的蛋白）增强。这些分子调节细胞生长，并且它们的异常表达可引起恶性转化。本研究旨在探讨这些分子在口腔癌前病变和口腔鳞状细胞癌中的表达变化。应用免疫组织化学方法检测了55例口腔上皮前病变（OEPLs）和84例口腔鳞状细胞癌（OSCC）组织中Cyclin D1和CREPT的表达。研究结果与临床病理变量之间的关系。Cyclin D1和CREPT在OSCC中的表达水平高于OEPL。此外，在不同级别的OEPL和OSCC病变中，cyclin D1的表达存在统计学显著差异。在口腔鳞状细胞癌中，CREPT的表达在性别、T分期和分化程度上存在统计学差异。此外，这两种分子的表达与术后转移和浸润方式显著相关。cyclin D1和CREPT的表达依赖于口腔上皮病变的发展和进展，这些分子可能影响OSCC的临床病理行为。
Cyclin D1 is the most essential progressive regulator of the cell cycle, and its transcription is enhanced by CREPT (cell cycle-related and expression-elevated protein in tumour). These molecules regulate cell growth, and their aberrant expression can cause malignant transformation. In this study, the expression of these molecules was explored to investigate the molecular alterations in oral precancerous lesions and squamous cell carcinoma. Cyclin D1 and CREPT expression was examined immunohistochemically in tissue specimens from 55 patients with oral epithelial precursor lesions (OEPLs) and 84 patients with oral squamous cell carcinoma (OSCC). Associations between the results and clinicopathological variables were examined. Cyclin D1 and CREPT expression levels were higher in OSCC than in OEPLs. Furthermore, there were statistically significant differences in cyclin D1 expression among the different grades of OEPLs and OSCC lesions. In OSCC, there were statistically significant differences in CREPT expression according to sex, T stage, and degree of differentiation. In addition, the expression of both molecules was significantly correlated with postoperative metastasis and modes of invasion. The expression of cyclin D1 and CREPT was found to depend upon the state of development and progression of the oral epithelial lesions, and clinicopathological behaviours might be affected by these molecules in OSCC.