An Engineering Model to Test for Sensory Reweighting: Nonhuman Primates Serve as a Model for Human Postural Control and Vestibular Dysfunction
An Engineering Model to Test for Sensory Reweighting: Nonhuman Primates Serve as a Model for Human Postural Control and Vestibular Dysfunction
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测试感觉重估的工程模型：非人类灵长类动物作为人类姿势控制和前庭功能障碍的模型
DOI：
10.1115/1.4038157
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lewis, Richard F.
中科院分区：
文献类型：
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作者：
Thompson, Lara A.;Haburcakova, Csilla;Goodworth, Adam D.;Lewis, Richard F.
迫切需要定量动物模型来为康复平衡疗法的研究提供概念证明（例如，侵入性前庭假体）和在人类临床试验之前或与人类临床试验相结合的治疗反应。本文介绍了一种新的方法来建模的非人灵长类动物的姿势控制系统。我们的观察，恒河猴和人类甚至远程相似的姿势控制，激励恒河猴作为研究前庭功能障碍，以及前庭假体辅助状态，对人类姿势控制的影响的模型的进一步应用。以前，系统识别方法和模型仅用于描述人体姿势。然而，在这里，我们利用伪随机，滚动倾斜平衡平台的刺激，扰乱姿势的恒河猴在正常和轻度前庭（平衡）损失状态。通过刺激-响应曲线和传递函数结果，确定了恒河猴躯干摇摆与平台侧倾的关系。然后使用反馈控制器模型来探索感觉重新加权（即，感觉依赖的变化），这防止了动物从倾斜平台上跌落。结论涉及非人灵长类动物的正常感觉状态和轻度前庭损失的状态的感觉重新加权导致有意义的见解。这第一阶段的努力，在非人类灵长类动物的平衡控制系统的模型是必不可少的，对侵入性康复（平衡）技术对灵长类动物的姿势控制的影响，并最终，人类未来的调查。
Quantitative animal models are critically needed to provide proof of concept for the investigation of rehabilitative balance therapies (e.g., invasive vestibular prostheses) and treatment response prior to, or in conjunction with, human clinical trials. This paper describes a novel approach to modeling the nonhuman primate postural control system. Our observation that rhesus macaques and humans have even remotely similar postural control motivates the further application of the rhesus macaque as a model for studying the effects of vestibular dysfunction, as well as vestibular prosthesis-assisted states, on human postural control. Previously, system identification methodologies and models were only used to describe human posture. However, here we utilized pseudorandom, roll-tilt balance platform stimuli to perturb the posture of a rhesus monkey in normal and mild vestibular (equilibrium) loss states. The relationship between rhesus monkey trunk sway and platform roll-tilt was determined via stimulus–response curves and transfer function results. A feedback controller model was then used to explore sensory reweighting (i.e., changes in sensory reliance), which prevented the animal from falling off of the tilting platform. Conclusions involving sensory reweighting in the nonhuman primate for a normal sensory state and a state of mild vestibular loss led to meaningful insights. This first-phase effort to model the balance control system in nonhuman primates is essential for future investigations toward the effects of invasive rehabilitative (balance) technologies on postural control in primates, and ultimately, humans.