Malignant versus benign nodules at CT screening for lung cancer: Comparison of thin-section CT findings
Malignant versus benign nodules at CT screening for lung cancer: Comparison of thin-section CT findings
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DOI：
10.1148/radiol.2333031018
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发表时间：
2004-12-01
期刊：
影响因子：
19.7
通讯作者：
Doi, K
中科院分区：
文献类型：
--
作者：
Li, F;Sone, S;Doi, K
目的：为了评价恶性结节的薄层CT（CT）特征的基础上的整体外观（纯磨玻璃样阴影[GGO]，混合GGO，或实性阴影）与良性nodels.Materials和方法的外观比较：机构审查委员会的批准和患者的同意。在低剂量CT筛查（17892次检查）中发现的747个可疑肺结节中进行了随访诊断CT。在747个结节中，222个在薄层CT（1 mm准直）上进行了评估，其中包括59个癌症和163个良性结节（3-20 mm）。分析了恶性与良性结节的薄层CT表现，包括单纯GGO（17 vs 12个病灶）、混合GGO（27 vs 29个病灶）或实性阴影（15 vs 122个病灶）。Fisher精确独立性检验用于比较良性和恶性结节在形状、边缘和内部特征方面的差异。结果：在单纯GGO结节中，圆形结节多见于恶性结节（11/17，65%）（2/12，17%; P= 0.02; PPV，85%）;混合型GGO是一种边缘GGO、中心高密度区的亚型，在恶性病变中更常见（11/27，41%）比良性病变（2/29，7%; P= 0.004; PPV，85%）。在实性结节中，多边形、边缘光滑或稍光滑的恶性结节的出现率低于良性结节（多边形：7%比38%，P= 0.02;边缘光滑或稍光滑：0%比63%，P = 0.05）。
Purpose: To evaluate thin-section computed tomographic (CT) characteristics of malignant nodules on the basis of overall appearance ( pure ground-glass opacity [GGO], mixed GGO, or solid opacity) in comparison with the appearance of benign nodules.Materials and Methods: Institutional review board approval and patient consent were obtained. Follow-up diagnostic CT was performed in 747 suspicious pulmonary nodules detected at low-dose CT screening (17892 examinations). Of 747 nodules, 222 were evaluated at thin-section CT (1-mm collimation), which included 59 cancers and 163 benign nodules (3-20 mm). Thin-section CT findings of malignant versus benign nodules with pure GGO (17 vs 12 lesions), mixed GGO ( 27 vs 29 lesions), or solid opacity (15 vs 122 lesions) were analyzed. Fisher exact test for independence was used to compare differences in shape, margin, and internal features between benign and malignant nodules. Positive predictive value (PPV) was analyzed when a category was significantly different from the others.Results: Among nodules with pure GGO, a round shape was found more frequently in malignant lesions (11 of 17, 65%) than in benign lesions ( two of 12, 17%; P=.02; PPV, 85%); mixed GGO, a subtype with GGO in the periphery and a high-attenuation zone in the center, was seen much more often in malignant lesions (11 of 27, 41%) than in benign lesions (two of 29, 7%; P=.004; PPV, 85%). Among solid nodules, a polygonal shape or a smooth or somewhat smooth margin was present less frequently in malignant than in benign lesions (polygonal shape: 7% vs 38%, P=.02; smooth or somewhat smooth margin: 0% vs 63%, P