Epithelial to mesenchymal transition in head and neck squamous cell carcinoma.
Epithelial to mesenchymal transition in head and neck squamous cell carcinoma.
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DOI：
10.1016/j.oraloncology.2012.10.009
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发表时间：
2013-04
期刊：
影响因子：
4.8
通讯作者：
Pan, Quintin
中科院分区：
文献类型：
--
作者：
Smith, Ashley;Teknos, Theodoros N.;Pan, Quintin
上皮细胞向间质细胞转化（EMT）是一个动态的细胞过程，对于转移性疾病的发展至关重要。在EMT期间，具有上皮特征的肿瘤细胞通过调节细胞极性和粘附而转变为具有间充质特征的肿瘤细胞。EMT的两个标志性蛋白E-Cadherin和Vimentin在EMT过程中通过多种信号转导途径受到严格控制。表皮生长因子（EGF）和转化生长因子β（TGFβ）通过调节一组不同的转录因子（包括Snail和Twist）促进EMT。Snail、Twist和Slug是通过直接调节参与细胞粘附、迁移和侵袭的基因而诱导EMT的组成部分。本文综述了HNSCC中EMT的相关文献。了解EMT的作用将为疾病进展的发病机制提供见解，并可能导致转移性HNSCC的新型抗癌疗法的开发。
Epithelial to mesenchymal transition (EMT) is a dynamic cellular process that is essential for the development of metastatic disease. During EMT, a tumor cell with epithelial characteristics transitions to a tumor cell with mesenchymal characteristics through modulation of cell polarity and adhesion. Two hallmark EMT proteins, E-Cadherin and Vimentin, are tightly controlled during EMT through multiple signal transduction pathways. Epidermal growth factor (EGF) and transforming growth factorβ (TGFβ) promote EMT by regulating a distinct set of transcription factors, including Snail and Twist. Snail, Twist, and Slug are integral to the induction of EMT through direct regulation of genes involved in cellular adhesion, migration, and invasion. This review highlights the current literature on EMT in HNSCC. Understanding the role of EMT will provide insight to the pathogenesis of disease progression and may lead to the development of novel anti-cancer therapeutics for metastatic HNSCC.
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N-钙粘着蛋白在乳腺癌细胞中的外源表达会诱导细胞迁移，侵袭和转移。
影响因子：
7.8
作者：
Hazan, R B;Phillips, G R;Qiao, R F;Norton, L;Aaronson, S A
通讯作者：
Aaronson, S A
影响因子：
4
作者：
Joseph, Mathew J.;Dangi-Garimella, Surabbi;Munshi, Hidayatullah G.
通讯作者：
Munshi, Hidayatullah G.
影响因子：
3.4
作者：
Dohadwala, Mariam;Wang, Guanyu;John, Maie A. St.
通讯作者：
John, Maie A. St.
影响因子：
4.8
作者：
Huang, Chi-Hung;Yang, Wen-Hao;Yang, Muh-Hwa
通讯作者：
Yang, Muh-Hwa
DOI：
10.1145/1980534.1980540
发表时间：
2010-01-01
期刊：
SECURITY INFORMATICS
影响因子：
--
作者：
Chen, Yi-Da;Abbasi, Ahmed;Chen, Hsinchun
通讯作者：
Chen, Hsinchun