Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study
Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study
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DOI：
10.1136/jnnp.2003.032417
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发表时间：
2004-11-01
影响因子：
11
通讯作者：
Caramia, F
中科院分区：
文献类型：
--
作者：
Antonini, G;Mainero, C;Caramia, F
1型强直性肌营养不良（DM 1）的脑受累特征为皮质萎缩和白色病变。我们比较了22例DM 1患者的磁共振成像衍生的灰质图与匹配的健康对照组，使用基于体素的形态测量来评估DM 1的全球和区域皮质萎缩的扩展，以及其与临床和遗传特征的关系。患者的脑组织体积显著减少。灰质体积与年龄呈负相关，这种负相关性在DM1比对照组显着增强。无论是临床和遗传特征，也没有白色物质病变与皮质萎缩。灰质萎缩主要位于双侧额顶叶、双侧颞中回和左侧上级颞枕回。
Brain involvement in myotonic dystrophy type 1 (DM1) is characterised by cortical atrophy and white matter lesions. We compared the magnetic resonance imaging derived grey matter maps of 22 DM1 patients with those of matched, healthy controls using voxel based morphometry to evaluate the extension of global and regional cortical atrophy in DM1, as well as its relationships with clinical and genetic features. Patients had significantly reduced brain tissue volumes. Grey matter volume was inversely correlated with age; this inverse correlation was significantly stronger in DM1 than in controls. Neither the clinical and genetic characteristics nor white matter lesions were correlated with cortical atrophy. Grey matter atrophy was located mainly in the bilateral frontal and parietal lobes, in the bilateral middle temporal gyrus, and in the left superior temporal and occipital gyrus.