Outpatient cervical ripening with nitric oxide donor isosorbide mononitrate prior to induction of labor
Outpatient cervical ripening with nitric oxide donor isosorbide mononitrate prior to induction of labor
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DOI：
10.1016/j.ijgo.2007.09.027
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发表时间：
2008-04-01
影响因子：
3.8
通讯作者：
Saber, Aza S.
中科院分区：
文献类型：
--
作者：
Habib, Sherif M.;Emam, Safa S.;Saber, Aza S.
目的：探讨门诊阴道给药单硝酸异山梨酯（IMN）促宫颈成熟的有效性和安全性。研究方法：一项前瞻性、双盲、安慰剂对照、随机临床试验，对102例宫颈不良的单胎足月妊娠妇女进行随机分配，在入院引产前接受门诊阴道内IMN或安慰剂。主要结果变量是从入院到分娩的时间。次要结局包括胎儿和母亲发病率、分娩特征和剖宫产率。结果：IMN组和安慰剂组的入院-分娩间隔分别为13.45 +/- 6.63和20.12 +/- 8.19 h（P=0.0001）。在IMN患者中，62.75%的患者需要使用甘草次酸促进宫颈成熟，而安慰剂组为90.2%（P=0.002）。IMN组收缩过速发生率明显低于对照组（P
Objective: To examine the effectiveness and safety of outpatient vagina[ administration of isosorbide mononitrate (IMN) to induce cervical ripening. Methods: A prospective, double-blind, placebo-controlled, randomized clinical trial was conducted on 102 singleton term pregnant women with unfavorable cervices who were randomly assigned to receive outpatient intravaginal IMN or placebo before admission for induction of labor. The main outcome variable was time from hospital admission to delivery. Secondary outcomes included fetal and maternal morbidity, labor characteristics, and incidence of cesarean delivery. Results: The admission-delivery interval was 13.45 +/- 6.63 and 20.12 +/- 8.19 h (P=0.0001) for the IMN and placebo groups, respectively. Of the IMN patients 62.75% needed prostaglandins for cervical ripening versus 90.2% with placebo (P=0.002). The incidence of tachysystole was significantly Lower in the IMN group (P