A 4-YEAR SURVEY OF ANTIMICROBIAL SUSCEPTIBILITY TRENDS FOR ISOLATES FROM CATTLE WITH BOVINE RESPIRATORY-DISEASE IN NORTH-AMERICA
A 4-YEAR SURVEY OF ANTIMICROBIAL SUSCEPTIBILITY TRENDS FOR ISOLATES FROM CATTLE WITH BOVINE RESPIRATORY-DISEASE IN NORTH-AMERICA
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DOI：
10.1128/jcm.32.3.725-731.1994
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发表时间：
1994-03-01
影响因子：
9.4
通讯作者：
CASE, CA
中科院分区：
文献类型：
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作者：
WATTS, JL;YANCEY, RJ;CASE, CA
确定了 1988 年至 1992 年分离的牛呼吸道疾病 (BRD) 病原体的抗菌药物敏感性趋势。该研究中总共使用了 880 株代表溶血巴氏杆菌、多杀性巴氏杆菌和睡眠嗜血杆菌的分离株。总体而言，溶血巴氏杆菌和多杀性巴氏杆菌菌株经常遇到对氨苄西林、四环素、红霉素和磺胺二甲嗪的耐药性。头孢噻呋是一种广谱头孢菌素，最初于 1988 年上市，用于治疗 BRD，对所测试的 BRD 病原体非常有效； 90%的测试菌株中头孢噻呋的 MIC 小于或等于 0.06 μg/ml。对壮观霉素的耐药性根据所使用的断点而变化。观察到 BRD 病原体对替米考星（一种新的大环内酯类抗菌剂）的敏感性逐年存在显着变化。易感溶血性巴氏杆菌比例从第二年的84.7%到第三年的7.1%和第四年的78.2%。在多杀性巴氏杆菌菌株中观察到类似的波动。
The antimicrobial susceptibility trends of bovine respiratory disease (BRD) pathogens isolated from 1988 to 1992 were determined. A total of 880 isolates representing Pasteurella haemolytica, Pasteurella multocida, and Haemophilus somnus were used in the study. Overall, resistance to ampicillin, tetracycline, erythromycin, and sulfamethazine was frequently encountered among strains of P. haemolytica and P. multocida. Ceftiofur, an extended-spectrum cephalosporin originally marketed in 1988 for the treatment of BRD, was very active against the BRD pathogens tested; the MIC of ceftiofur for 90% of isolates tested was less than or equal to 0.06 mu g/ml. Resistance to spectinomycin varied on the basis of the breakpoint used. Substantial variation in the year-to-year susceptibility of BRD pathogens to tilmicosin, a new macrolide antimicrobial agent, was observed. The proportion of susceptible P. haemolytica isolates ranged from 84.7% in the second year to 7.1% in the third year and 78.2% in the fourth year. Similar fluctuations were observed with strains of P. multocida.