Delivery of bioactive conjugated linoleic acid with self-assembled amylose-CLA complex.
Delivery of bioactive conjugated linoleic acid with self-assembled amylose-CLA complex.
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DOI：
10.1021/jf9016306
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发表时间：
2009-07
影响因子：
6.1
通讯作者：
Ying Yang;Zheng-biao Gu;Genyi Zhang
中科院分区：
文献类型：
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作者：
Ying Yang;Zheng-biao Gu;Genyi Zhang
研究了通过自组装直链淀粉-共轭亚油酸（CLA）配合物与β -环糊精(BCD)-共轭亚油酸（CLA）配合物的传递体系。通过差示扫描量热法、x射线衍射和傅里叶变换红外光谱分析证实了CLA与直链淀粉或BCD的成功络合。直链淀粉- cla复合物的产率和络合率分别为71.9和1.4%，BCD-CLA复合物的产率和络合率分别为42.3和7.7%。而直链淀粉-CLA复合物对CLA的抗氧化保护作用优于BCD-CLA复合物，热重分析表明直链淀粉与CLA之间存在较强的络合作用。在模拟小肠条件下，BCD-CLA复合物释放了15.9%的CLA，而直链淀粉-CLA复合物释放了95.6%的CLA。这些结果表明，以食物成分相互作用的自然方式自组装的直链淀粉-脂复合物可用于保护和将功能性脂质或其他生物活性成分输送到目标小肠中以供吸收。
A delivery system for bioactive conjugated linoleic acid (CLA) through a self-assembled amylose-CLA complex was investigated in comparison with a beta-cyclodextrin (BCD)-CLA complex. Successful complexation between CLA and amylose or BCD was confirmed by differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared spectral analysis. The yield and complexing percentages were 71.9 and 1.4% for the amylose-CLA complex and 42.3 and 7.7% for the BCD-CLA complex, respectively. However, the amylose-CLA complex showed a better antioxidative protection effect on CLA than BCD-CLA complex, supporting a strong complexing interaction between CLA and amylose shown by thermogravimetric analysis. Compared to 15.9% of CLA released from the BCD-CLA complex under simulated small intestine conditions, 95.6% of CLA was released from the amylose-CLA complex. These results indicate that an amylose-lipid complex self-assembled in the natural way of food component interaction can be used to protect and deliver functional lipids or other bioactive components into the targeted small intestine for absorption.