EXCITABILITY, LENGTH TENSION RELATION AND KINETICS OF UTERINE MUSCLE CONTRACTION IN RELATION TO HORMONAL STATUS
EXCITABILITY, LENGTH TENSION RELATION AND KINETICS OF UTERINE MUSCLE CONTRACTION IN RELATION TO HORMONAL STATUS
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DOI：
10.1113/jphysiol.1954.sp005216
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发表时间：
1954-01-01
影响因子：
5.5
通讯作者：
GOODALL, M
中科院分区：
文献类型：
--
作者：
CSAPO, A;GOODALL, M
Effect of alternating current (a.c.) stimulation of varying frequencies and durations was studied on the rabbit uterus in vitro. A few experiments were carried out with single square direct current (d.c.) pulses. Maximum tension was only obtained by a.c. stimulus between the frequency range 30-100. Uterine muscle under progesterone domination was found to have a significantly higher threshold than that dominated by estrogen. Strength-duration-tension relation indicated that the uterine muscle requires a relatively long time for activation as compared with skeletal muscle. Preliminary experiments observing the effect of "quick release" supported this assumption. The length-tension diagrams indicated that the maximum tension is obtained at the resting length. Shape of the diagrams depended on the strength of the stimulation and the dominant ovarian hormone. Kinetics of isotonic shortening of the uterus were studied as a function of load and were found to obey Hill''s equation.
