The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase.
The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase.
复制标题
DOI：
10.1155/2016/3869610
复制
发表时间：
2016
影响因子：
--
通讯作者：
Giorgio V
中科院分区：
文献类型：
--
作者：
Kaludercic N;Giorgio V
以线粒体为靶点的活性氧和活性氮是疾病发病机制中的主要致病因素。线粒体通透性转换孔（PTP）是由钙和ROS/RNS修饰调节的巨通道，并且已经描述了其在许多病理生理事件中起关键作用，因为长时间的通道开放导致细胞死亡。最近发现ATP合酶的二聚体形成PTP，并且ROS/RNS引起的翻译后修饰也通过ATP合酶催化的调节影响细胞生物能量学，这一事实揭示了这些修饰在细胞中的双重功能。在这里，我们描述了线粒体作为一个主要的生产网站和ROS/RNS的目标，并讨论了病理生理条件下，氧化和亚硝化修饰调节ATP合酶的催化和成孔活性。
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) targeting mitochondria are major causative factors in disease pathogenesis. The mitochondrial permeability transition pore (PTP) is a mega-channel modulated by calcium and ROS/RNS modifications and it has been described to play a crucial role in many pathophysiological events since prolonged channel opening causes cell death. The recent identification that dimers of ATP synthase form the PTP and the fact that posttranslational modifications caused by ROS/RNS also affect cellular bioenergetics through the modulation of ATP synthase catalysis reveal a dual function of these modifications in the cells. Here, we describe mitochondria as a major site of production and as a target of ROS/RNS and discuss the pathophysiological conditions in which oxidative and nitrosative modifications modulate the catalytic and pore-forming activities of ATP synthase.