Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study.
Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study.
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DOI：
10.1016/j.jaad.2016.05.011
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发表时间：
2016-10
影响因子：
13.8
通讯作者：
Li, Wen-Qing
中科院分区：
文献类型：
--
作者：
Wei, Erin X.;Qureshi, Abrar A.;Han, Jiali;Li, Tricia Y.;Cho, Eunyoung;Lin, Jennifer Y.;Li, Wen-Qing
关键词：
原位黑色素瘤的发病率正在上升，但人们对其特征知之甚少。目的：探讨原位黑色素瘤的诊断趋势和临床特点。黑色素瘤病例前瞻性收集自1976-2010年的《护士健康研究》和1986-2010年的《卫生专业人员随访研究》。女性的发病率从每10万人年2例增加到42例，男性从11例增加到73例，超过了侵袭性黑色素瘤的增长速度。黑色素瘤死亡率最初在随访期增加，然后趋于平稳。男性比女性更容易在上半身发生原位黑色素瘤(p<；0.001)。侵袭性黑色素瘤的诊断年龄比原位黑色素瘤年轻(p<；0.001)，而且比原位黑色素瘤更有可能出现在下肢(p<；0.001)。这是一项严格的描述性研究，没有对机制进行审查。我们在原位黑色素瘤和侵袭性黑色素瘤中发现了流行病学和临床上的差异，这支持了对病因途径差异的进一步检查。尽管原位检测相对于侵袭性病变有所增加，但死亡率仍未得到改善，这进一步突出了改进侵袭性黑色素瘤特异性临床筛查特征的必要性。
The incidence of melanoma in situ is rising, but little is known about its characteristics. To determine trends in diagnosis and clinical features of melanoma in situ. Incident cases of melanoma were collected prospectively from the Nurses’ Health Study from 1976–2010 and Health Professionals Follow-up Study from 1986–2010. MIS incidence increased from 2 to 42 per 100,000-person-year (100KPY) among women, and from 11 to 73 per 100KPY among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on upper half of the body (p<0.001). Invasive melanomas were diagnosed at a younger age than melanoma in situ (p<0.001), and were more likely to be found on the lower extremities than in situ melanomas (p<0.001). This is a strictly descriptive study without examination into mechanisms. We found epidemiologic and clinical differences in in situ and invasive melanomas, which support further examination into the variations in etiologic pathways. The lack of improvement in mortality despite increase in detection of in situ relative to invasive lesions further highlight the need to improve invasive melanoma-specific clinical screening features.
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DOI：
10.1038/jid.2008.374
发表时间：
2009-06
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1038/jid.2008.423
发表时间：
2009-07
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
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影响因子：
10.3
作者：
Jemal, A;Devesa, SS;Hartge, P
通讯作者：
Hartge, P
影响因子：
3.7
作者：
Balch, Charles M.;Thompson, John F.;Sondak, Vernon K.
通讯作者：
Sondak, Vernon K.
影响因子：
2.3
作者：
Coory, M;Baade, P;Ring, I
通讯作者：
Ring, I