Cross-sectional and longitudinal associations between serum testosterone concentrations and hypertension: Results from the Fangchenggang Area Male Health and Examination Survey in China.
Cross-sectional and longitudinal associations between serum testosterone concentrations and hypertension: Results from the Fangchenggang Area Male Health and Examination Survey in China.
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血清睾酮浓度与高血压之间的横断面和纵向关联：中国防城港地区男性健康与检查调查的结果。
DOI：
10.1016/j.cca.2018.08.027
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发表时间：
2018
影响因子：
5
通讯作者：
Mo Zengnan
中科院分区：
文献类型：
--
作者：
Jiang Yonghua;Ye Juan;Zhao Mukun;Tan Aihua;Zhang Haiying;Gao Yong;Lu Zheng;Wu Chunlei;Hu Yanling;Wang Qiuyan;Yang Xiaobo;Mo Zengnan
背景低浓度的睾酮已被认为是高血压的危险因素，但其在高血压发病中的作用尚未得到很好的研究。我们在早期横断面调查结果的基础上进行了一项队列研究。我们建立了睾酮浓度与高血压之间的关系。方法收集2427名年龄在17-88岁的健康男性的数据进行横断面研究。对853例基线无高血压的有代表性的人群进行为期4年的随访，分析不同性别人群性激素水平的差异，用二元Logistic回归模型估计相对危险度(RR)。结果横断面分析中，高血压人群的血清总睾酮(TT)、游离睾酮(FT)和生物可利用睾酮(BT)浓度均低于非高血压人群。Logistic回归分析显示TT、BT、FT与高血压呈负相关。此外，从最低三分位组到最高三分位组，优势比(OR)呈递减趋势。经多因素校正后，FT、BT与高血压的相关性减弱。仅TT中三分位组和TT、FT、BT最高三分位组仍有统计学意义。在纵向分析中，TT低的参与者的4年高血压发病率高于TT高的参与者。TT中、高三分位组的RR分别为0.35(0.22~0.57)和0.30(0.18~0.50)(P为Trend<；0.001)。结论男性血清TT、FT、BT浓度与血压呈负相关，TT独立于年龄和体重指数(BMI)影响高血压的发生。此外，TT可作为高血压的危险标记物，用于识别高危个体。
BackgroundLow testosterone concentrations have been suggested as a risk factor for hypertension, but their contribution to the development of hypertension is not well studied. We carried out a cohort study based on the results of an earlier cross-sectional investigation. We established the association between testosterone concentrations and hypertension.MethodData on 2427 healthy male subjects, aged from 17 to 88 y, were collected for the cross-sectional study. A representative sample of 853 individuals who did not suffer from hypertension at baseline was followed up for 4 y. Differences between the tertiles groups of sex hormones were analyzed, relative risks (RR) were estimated using binary logistic regression model.ResultsIn the cross-sectional analysis, the serum total testosterone (TT), free testosterone (FT), and bioavailable testosterone (BT) concentrations of the hypertensive population were lower than those of the non-hypertensive population. Binary logistic regression analysis showed that TT, BT, and FT were inversely associated with hypertension. Moreover, decreasing odds ratio (OR) was observed from the lowest tertile group to the highest tertile group. After multivariate adjustment, the correlation between FT, BT, and hypertension was attenuated. Statistically significant differences remained only in the middle tertile group of TT and in the highest tertile group of TT, FT, and BT. In the longitudinal analysis, the 4-y incidence of hypertension was higher in participants with lower TT than in those with higher TT. Subjects in the middle and highest tertile groups of TT had an RR of 0.35 (0.22–0.57) and 0.30 (0.18–0.50), respectively (P for trend <0.001). After further adjustments, these associations still remained statistically significant.ConclusionsSerum TT, FT, and BT concentrations were inversely associated with blood pressure in man, and TT independent of age and body mass index (BMI) influences the development of hypertension. Furthermore, TT can be employed as a risk marker for hypertension in the identification of high-risk individuals.