Congenital lymphocytic choriomeningitis virus syndrome: A disease that mimics congenital toxoplasmosis or cytomegalovirus infection
Congenital lymphocytic choriomeningitis virus syndrome: A disease that mimics congenital toxoplasmosis or cytomegalovirus infection
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DOI：
10.1542/peds.100.1.e9
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发表时间：
1997-07-01
期刊：
影响因子：
8
通讯作者：
Bale, JF
中科院分区：
文献类型：
--
作者：
Wright, R;Johnson, D;Bale, JF
目标。摘要目的探讨子宫内感染淋巴细胞性脉络丛脑膜炎（LCM）病毒的临床特点，这是一种罕见的先天性病毒感染原因。1994年和1995年在美国中西部出生的三名婴儿，其临床特征和血清学研究与先天性LCM病毒感染一致，并通过对1955年至1996年医学文献的回顾确定了先天性感染病例。对26例经血清学证实的先天性LCM病毒感染患儿进行了分析。22名婴儿是足月妊娠的产物，出生体重从2384到4400 g不等（中位数为3520 g）。眼异常、大头畸形或小头畸形是最常见的新生儿特征。21名婴儿（88%）出生时患有绒毛膜视网膜病变，10名婴儿（43%）出生时患有大头畸形（头围90百分位数），3名婴儿（13%）患有小头畸形（头围）
Objective. To describe the clinical characteristics of intrauterine infection with lymphocytic choriomeningitis (LCM) virus, an uncommonly recognized cause of congenital viral infection.Patients. Three infants born in the midwestern United States in 1994 and 1995 with clinical features and serologic studies consistent with congenital LCM virus infection and cases of congenital infection identified by review of the medical literature between 1955 and 1996.Results. Twenty-six infants with serologically confirmed congenital LCM virus infection were identified. Twenty-two infants were products of term gestations, and birth weights ranged from 2384 to 4400 g (median, 3520 g). Ocular abnormalities, macrocephaly, or microcephaly were the most commonly identified neonatal features. Twenty-one infants (88%) had chorioretinopathy, 10 (43%) had macrocephaly (head circumference >90th percentile) at birth, and 3 (13%) were microcephalic (head circumference