Development of short latency vestibular evoked potentials in the neonatal rat
Development of short latency vestibular evoked potentials in the neonatal rat
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DOI：
10.1016/s0378-5955(99)00137-9
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发表时间：
1999-11-01
期刊：
影响因子：
2.8
通讯作者：
Sohmer, H
中科院分区：
文献类型：
--
作者：
Freeman, S;Plotnik, M;Sohmer, H
本实验观察了新生大鼠短潜伏期前庭诱发电位（VsEPs）的发育过程。使用适当的刺激（线性或角加速度脉冲）和头部方向，在各种前庭终末器官（椭圆囊：x-VsEP;球囊：z-VsEP;外侧半规管：a-VsEP）引起的反应进行了测量，在不同年龄的大鼠幼崽出生后（PND）5和30天之间，并与成年动物的记录。结果发现，VsEPs最初出现在PND 6（x-VsEPs和z-VsEPs）或7（a-VsEPs），到PND 8，所有动物均可记录到这三种反应。第一波的反应，产生于初级感觉神经和反映终末器官的活动，达到成人laveli和振幅的PND 10，显示快速成熟的反应。另一方面，听觉反应在较晚的阶段（从PND 11开始）发展。前庭和听觉活动之间的差异成熟的可能机制进行了讨论。(C)1999 Elsevier Science B. V.保留所有权利。
The development of short latency vestibular evoked potentials (VsEPs) was investigated in the neonatal rat. Using the appropriate stimulus (linear or angular acceleration impulses) and head orientation, responses elicited in various vestibular end-organs (utricle: x-VsEP; saccule: z-VsEP; lateral semi-circular canal: a-VsEP) were measured in rat pups at various ages between post-natal days (PND) 5 and 30, and compared to those recorded from adult animals. It was found that the VsEPs initially appeared on PND 6 (x-VsEPs and z-VsEPs) or 7 (a-VsEPs), and that by PND 8 the three responses could be recorded in all animals. The first wave of the responses, generated in the primary sensory nerve and reflecting end-organ activity, reached adult latencies and amplitudes by PND 10, showing rapid maturity of the responses. Auditory responses, on the other hand, develop at a later stage (from PND 11). The possible mechanisms involved in this differential maturation between vestibular and auditory activity are discussed. (C) 1999 Elsevier Science B.V. All rights reserved.