EPILEPSY IN MULTIPLE-SCLEROSIS
EPILEPSY IN MULTIPLE-SCLEROSIS
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DOI：
10.1159/000117350
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发表时间：
1990-07-01
影响因子：
2.4
通讯作者：
CAZZULLO, CL
中科院分区：
文献类型：
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作者：
GHEZZI, A;MONTANINI, R;CAZZULLO, CL
在 2,353 名多发性硬化症 (MS) 患者的一系列研究中，40 名受试者出现癫痫发作，总体患病率为 1.70%。确诊 MS 病例的患病率为 2.33%（34/1,459），可能病例为 0.58（3/518），可能病例为 0.79（3/376）。 26 名患者为女性，14 名患者为男性。 13 例患者在多发性硬化症发病前就已开始癫痫； 4 名患者两种疾病同时发病；在 23 名患者中，多发性硬化症发病后出现癫痫。癫痫发作频率与 MS 病程之间以及癫痫发作频率与 MS 严重程度之间均未发现相关性。 12例患者进行磁共振检查：3例发现邻近大脑皮层的斑块。脑电图显示 11 例患者有阵发性放电（局灶性 2 例，弥漫性 9 例）。 15 名患者中发现缓慢的 theta 和/或 delta 活动（7 名患者为局灶性，6 名患者为弥漫性，2 名患者同时具有局灶性和弥漫性）。 14 名患者的脑电图正常。仅在 4 名患者中发现了除 MS 以外的可能病因：3 名患者为颅骨外伤，1 名患者为脑膜炎。我们对大量 MS 人群的研究证实，MS 与癫痫的风险高于一般人群。
In a series of 2,353 multiple sclerosis (MS) patients, 40 subjects presented seizures, with an overall prevalence of 1.70%. The prevalence was 2.33% (34/1,459) in definite MS cases, 0.58 in probable cases (3/518), 0.79 in possible cases (3/376). Twenty-six patients were females, 14 were males. In 13 cases, epilepsy had begun before MS onset; in 4 patients, the two diseases started contemporarily; in 23 patients, epilepsy followed MS onset. No relationship was found between frequency of seizures and course of MS nor between frequencey of seizures and MS severity. In 12 patients, magnetic resonance imaging was performed: plaques adjacent to the cerebral cortex were found in 3 cases. The electroencephalogram showed paroxysmal discharges in 11 patients (focal in 2, diffuse in 9). Slow theta and/or delta activity was found in 15 patients (focal in 7, diffuse in 6, both focal and diffuse in 2). The EEG was normal in 14 patients. Possible etiological factors other than MS were recognized in 4 patients only: cranial trauma in 3 , meningitis in 1. Our study on a large MS population confirms that MS is associated to a risk for epilepsy higher than that of the general population.