Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man.
Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man.
复制标题
估计人体中甲状腺素和三碘甲状腺原氨酸的分布以及甲状腺素到三碘甲状腺原氨酸的转化率。
DOI：
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发表时间：
1975
影响因子：
15.9
通讯作者：
T. Soma
中科院分区：
文献类型：
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作者：
M. Inada;K. Kasagi;S. Kurata;Y. Kazama;H. Takayama;K. Torizuka;M. Fukase;T. Soma
本文对5例正常人、4例甲减患者和3例甲减患者同时给予~(125)I标记的L-甲状腺素([~(125)I]T_4)和~(131)I标记的L三碘甲腺原氨酸([~(131)I]T_3)的外周代谢进行了研究。用三室法计算甲状腺激素不可逆地离开降解部位的周转率(Lambda 03)和池1(血清V1)、池3(所有组织，V3)的体积。除了周转研究外，在注射后4天、7天和10天的血清中，通过纸层析研究来确定体内T4/T3转换的比率。T4向T3的甲状腺外转化率(K12)也由房室分析估算出来。正常受试者利用和降解T3的T_3池的T_3分布体积(V=V_1+V_2+V_3)约为总分布体积的60%，而甲状腺外T_4池仅有25%位于细胞内，表明T_3主要是一种细胞内激素。
Studies on peripheral metabolism of simultaneously administered 125-I-labeled L-thyroxine ([125-I]T4) and 131-I labeled L-trilodothyronine ([131-I]T3) were performed in five normal subjects, in four patients with untreated hypothyroidism, and in 3 hypothyroid patients made euthyroid by the administration of T4. The fractional turnover rate (lambda 03) of thyroid hormones irreversibly leaving the site of degradation and the volumes of pool 1 (serum V1) of pool (interstitial fluid, V2), and of pool 3 (all tissues, V3)were obtained by using a three-compartment analysis. In addition to the turnover studies, the ratios for the in vivo T4 to T3 conversion were determined by paper chromatographic study in sera obtained 4, 7, and 10 daysafter the injection. The rate (K12) of the extrathyroidal conversion of T4 to T3 was also estimated by the compartment analysis. The T3 distribution volume (V3) of pool 3, in which T3 is utilized and degraded, was about 60% of totaldistribution volume (V=V1+V2+V3) in normal subjects, whereas only about 25% of the extrathyroidal T4 pool was in the intracellular compartment, indicating that T3 is predominantly an intracellular hormone..