Latent period and yield of chemically-induced skin tumors in chimeric mice.
Latent period and yield of chemically-induced skin tumors in chimeric mice.
复制标题
嵌合小鼠化学诱导皮肤肿瘤的潜伏期和产量。
DOI：
10.1016/0304-3835(80)90041-5
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发表时间：
1980
期刊：
影响因子：
9.7
通讯作者：
P. Iannaccone
中科院分区：
文献类型：
--
作者：
P. Iannaccone
研究了两种方法和两种不同亲代嵌合体对皮肤肿瘤的诱导作用。比较了几种嵌合体中肿瘤的产率和潜伏期。在具有长潜伏期和短潜伏期的小鼠株之间的嵌合体中，获得了短潜伏期。这些动物中的一些肿瘤来自于反应较晚的细胞类型。在同一只动物体内同时存在两种菌株的细胞可能会改变嵌合体中反应较晚的菌株衍生细胞的潜伏期。
The induction of skin tumors in chimeras produced by 2 methods and between 2 different parental sets was investigated. The yield and latent period of the tumors were compared in the several types of chimeras. In chimeras between strains of mice with long and short latent periods, a short latent period was obtained. Some of the tumors in these animals were derived from the late-responding cell type. The presence of cells from 2 strains in a single animal may modify the latent period of the late responding strain-derived cells in the chimeras.