Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
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精神分裂症风险增加的受试者前额叶 5-HT2A 受体结合减少
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
A. Bauer
中科院分区：
文献类型：
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作者：
R. Hurlemann;C. Boy;P. Meyer;H. Scherk;M. Wagner;H. Herzog;H. Coenen;K. Vogeley;P. Falkai;K. Zilles;W. Maier;A. Bauer
脑5-羟色胺-2A受体（5-HT 2AR）与精神分裂症的病理学和非典型抗精神病药物的治疗作用有关。然而，很少有人知道5-HT 2AR状态之前，精神分裂症的发病和抗精神病药物的暴露。我们使用[18F]阿坦色林和正电子发射断层扫描（PET）在一项初步研究中的6个人被怀疑是在精神分裂症的高风险和7个年龄匹配的控制，以测试的假设，区域5-HT 2AR结合改变的前驱期精神分裂症。分布容积比（DVR）作为5-HT 2AR可用性的代理显着降低，在前额叶皮层区域的高危受试者，暗示早期异常的多巴胺能神经传递，发病前的精神分裂症。
The brain serotonin-2A receptor (5-HT2AR) has been implicated in both the pathology of schizophrenia and the therapeutic action of atypical antipsychotics. However, little is known about the 5-HT2AR status before the onset of schizophrenia and before the exposure to antipsychotics. We used [18F] altanserin and positron emission tomography (PET) in a pilot study of 6 individuals suspected to be at elevated risk for schizophrenia and seven age-matched controls to test the hypothesis that regional 5-HT2AR binding is altered in the prodromal stages of schizophrenia. Distribution volume ratios (DVRs) as a proxy for 5-HT2AR availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities of serotonergic neurotransmission that antecede the onset of schizophrenia.
影响因子：
5.2
作者：
M. Laruelle;L. Kegeles;A. Abi-Dargham
通讯作者：
M. Laruelle;L. Kegeles;A. Abi-Dargham