An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome
An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome
复制标题
DOI：
10.1111/j.1365-2788.2006.00812.x
复制
发表时间：
2006-09-01
影响因子：
3.6
通讯作者：
Owen, A. M.
中科院分区：
文献类型：
--
作者：
Hinton, E. C.;Holland, A. J.;Owen, A. M.
到目前为止，对与Prader-Willi综合征（PWS）相关的过度饮食行为的研究主要集中在稳态和行为调查上。本研究的目的是研究奖励系统在这种饮食行为中的作用，在杏仁核和眶额皮质（OFC.Participants）的食物偏好的模式和神经基板的激励与PWS（n = 18）进行了一次食物偏好访谈，检查食物偏好，并告知食物相关的激励任务进行神经成像。13名PWS患者参加了正电子发射断层扫描（PET）研究，该研究的设计基于先前对非肥胖、非PWS对照的研究。在这项任务中，参与者被要求考虑食物的照片，并在两种条件下选择他们最喜欢吃的食物，一种是高刺激食物，一种是低刺激食物，根据每个参与者的喜好量身定制。为了比较食物偏好数据，12名非PWS个体被给予了一部分访谈。PWS个体表达了对不同食物的相对偏好，并且随着时间的推移表现出一致的偏好，特别是对甜食的偏好。PWS的参与者确实给予高激励条件下的食物比低激励条件下的食物显着更高的激励值。然而，杏仁核和内侧眶额皮层的激活与PWS患者所预测的高价值食物的前景无关。看来，激励动机单独在PWS患者中的作用不如那些没有综合征的人。这可能是由于PWS患者缺乏饱腹感而产生的压倒性的内在进食冲动，以及这种情况对大脑激励处理区域活动的影响。这样，这些奖励区域的活动可能就不能起到引导行为选择性地消费高偏好食物的作用。
Research into the excessive eating behaviour associated with Prader-Willi syndrome (PWS) to date has focused on homeostatic and behavioural investigations. The aim of this study was to examine the role of the reward system in such eating behaviour, in terms of both the pattern of food preferences and the neural substrates of incentive in the amygdala and orbitofrontal cortex (OFC).Participants with PWS (n = 18) were given a food preference interview to examine food preferences and to inform the food-related incentive task to be conducted during the neuroimaging. Thirteen individuals with PWS took part in the positron emission tomography (PET) study, the design of which was based on a previous study of non-obese, non-PWS controls. For the task, participants were asked to consider photographs of food and to choose the food they would most like to eat in two conditions, one of high and one of low incentive foods, tailored to each participant's preferences. For comparison of the food preference data, 12 non-PWS individuals were given one part of the interview.Individuals with PWS expressed relative liking of different foods and showed preferences that were consistent over time, particularly for sweet foods. The participants with PWS did give the foods in the high incentive condition a significantly higher incentive value than the foods in the low incentive condition. However, activation of the amygdala and medial OFC was not associated with the prospect of highly valued foods as predicted in those with PWS.It would appear that incentive motivation alone plays a less powerful role in individuals with PWS than in those without the syndrome. This is likely to be due to the overriding intrinsic drive to eat because of a lack of satiety in those with PWS, and the impact of this on activity in the incentive processing regions of the brain. Activity in such reward areas may not then function to guide behaviour selectively towards the consumption of high preference foods.