Phenomenology and Management of Subthalamic Stimulation-Induced Dyskinesia in Patients With Isolated Dystonia.
Phenomenology and Management of Subthalamic Stimulation-Induced Dyskinesia in Patients With Isolated Dystonia.
复制标题
孤立性肌张力障碍患者底丘脑刺激诱发的运动障碍的现象学和治疗。
DOI：
10.1002/mdc3.12946
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发表时间：
2020
影响因子：
4
通讯作者：
Ostrem,JillL
中科院分区：
文献类型：
--
作者：
Bledsoe,IanO;Dodenhoff,KristenA;SanLuciano,Marta;Volz,MonicaM;Starr,PhilipA;Markun,LeslieC;Ostrem,JillL
背景苍白球一直是治疗肌张力障碍的首选DBS靶点，但最近的研究表明，植入STP的患者有同等或更大的改善。1在刺激这个新靶点时，经常观察到短暂刺激诱导的运动障碍（SID），我们详细描述了4例植入DBS的患者所经历的SID现象结论SID可发生在局灶性、节段性、轴向或全身性分布中，可类似于帕金森病中观察到的左旋多巴诱导的舞蹈样运动障碍或肌张力障碍运动，并且通常是短暂的，可通过定制的DBS编程解决。提供者应该意识到，当治疗孤立性肌张力障碍时，在DBS治疗后可能会发生SID，而不是假设运动是潜在肌张力障碍恶化或扩散的结果。
BackgroundThe pallidum has been the preferred DBS target for dystonia, but recent studies have shown equal or greater improvement in patients implanted in the STN.1Transient stimulation‐induced dyskinesia (SID) is frequently observed when stimulating this novel target, and there are no previously published video case reports of this phenomenon.CasesWe describe in detail the SID phenomenology experienced by 4 patients who had been implanted with STN DBS for isolated dystonia.ConclusionsSID can occur in focal, segmental, axial, or generalized distribution, can resemble levodopa‐induced dyskinesia choreiform or dystonic movements observed in Parkinson’s disease, and is generally transient and resolves with customized DBS programming. Providers should be aware that SID can occur after STN DBS when treating isolated dystonia and not assume movements are the result of worsening or spread of the underlying dystonia.