Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.
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DOI：
10.3389/fimmu.2018.00276
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发表时间：
2018
影响因子：
7.3
通讯作者：
Arens R
中科院分区：
文献类型：
--
作者：
Panagioti E;Klenerman P;Lee LN;van der Burg SH;Arens R
多年来，预防性疫苗的重点是引发中和抗体，但越来越明显的是，T细胞介导的免疫在控制持续性病毒感染（如人类免疫缺陷病毒、巨细胞病毒和丙型肝炎病毒）中起着核心作用。目前，各种有前途的预防性疫苗，能够诱导大量的疫苗特异性T细胞反应，在临床前和临床研究中进行了研究。有令人信服的证据表明，T细胞的保护作用与T细胞应答的幅度和广度、记忆T细胞亚群的类型和归巢特性以及它们的细胞因子多功能性和代谢适应性有关。在这篇综述中，我们评估了这些决定慢性病毒性疾病和预防性疫苗开发背景下CD4+和CD8+ T细胞应答的定性和定量特性的关键因素。阐明T细胞介导的抗慢性病毒病原体的保护机制将有助于开发更有效、持久和安全的预防性T细胞疫苗。
For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with human immunodeficiency virus, cytomegalovirus, and hepatitis C virus. Currently, various promising prophylactic vaccines, capable of inducing substantial vaccine-specific T cell responses, are investigated in preclinical and clinical studies. There is compelling evidence that protection by T cells is related to the magnitude and breadth of the T cell response, the type and homing properties of the memory T cell subsets, and their cytokine polyfunctionality and metabolic fitness. In this review, we evaluated these key factors that determine the qualitative and quantitative properties of CD4+ and CD8+ T cell responses in the context of chronic viral disease and prophylactic vaccine development. Elucidation of the mechanisms underlying T cell-mediated protection against chronic viral pathogens will facilitate the development of more potent, durable and safe prophylactic T cell-based vaccines.