A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.
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群体药代动力学分析研究体外膜氧合对儿童头孢吡肟处置的影响。

DOI：
10.1097/pcc.0000000000001786
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发表时间：
2019
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
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通讯作者：
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中科院分区：
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文献类型：
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作者：
Zuppa,AthenaF;Zane,NicoleR;Moorthy,Ganesh;Dalton,HeidiJ;Abraham,Alan;Reeder,RonW;Carcillo,JosephA;Yates,AndrewR;Meert,KathleenL;Berg,RobertA;Sapru,Anil;Mourani,Peter;Notterman,DanielA;Dean,JMichael;Gastonguay,MarcR;

文献摘要

相似文献

目的：关于体外膜肺氧合对危重儿科患者头孢吡肟药代动力学影响的数据有限。目的是使用群体药代动力学模型描述接受体外膜氧合治疗的儿童中头孢吡肟的分布。设计：多中心，前瞻性观察性研究。设置：协作儿科重症监护研究网络的六个站点的儿科和心脏ICU。患者：17名接受体外膜氧合治疗的重症儿童（30天至< 2岁），他们在2014年1月4日至2015年8月24日期间接受头孢吡肟作为标准治疗。干预措施：无。测量和主要结果：
Objectives:Limited data exist on the effects of extracorporeal membrane oxygenation on pharmacokinetics of cefepime in critically ill pediatric patients. The objective was to describe cefepime disposition in children treated with extracorporeal membrane oxygenation using population pharmacokinetic modeling.Design:Multicenter, prospective observational study.Setting:The pediatric and cardiac ICUs of six sites of the Collaborative Pediatric Critical Care Research Network.Patients:Seventeen critically ill children (30 d to< 2 yr old) on extracorporeal membrane oxygenation who received cefepime as standard of care between January 4, 2014, and August 24, 2015, were enrolled.Interventions:None.Measurements and Main Results: