BRANCHED CHORDA TYMPANI NEURONS AND INTERACTIONS AMONG TASTE RECEPTORS
BRANCHED CHORDA TYMPANI NEURONS AND INTERACTIONS AMONG TASTE RECEPTORS
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DOI：
10.1002/cne.901580204
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发表时间：
1974-01-01
影响因子：
2.5
通讯作者：
MILLER, IJ
中科院分区：
文献类型：
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作者：
MILLER, IJ
使用普通银染色在大鼠的舌头中检查来自鼓索神经的神经纤维的前末端分支模式。将三叉神经的舌支在鼓索连接处附近单侧切开，并在处死动物前八至十天让这些纤维退化。发现前舌中鼓索纤维的终止仅限于菌状乳头的味蕾区域。舌头的对照侧在丝状乳头的共同上皮的基底层以及菌状乳头的侧壁中显示出普遍存在的纤维末端。这些纤维被认为是三叉神经起源的。舌头实验侧的 79% 的菌状乳头接收来自分支神经束的纤维。神经束内的分支点位于舌头深处，43% 的乳头位于味蕾下方 300-500 μ 处，36% 的菌状乳头位于味蕾下方约 125 μ 的基部，并且位于乳头内。这些数据证实了电生理学观察结果，即单个鼓索纤维接收来自多个味蕾的输入。假设在相邻味蕾中观察到的侧向抑制是由传入纤维分支点处的纤维输入相互作用引起的。从对鼓索神经纤维形态的理论考虑得出的结论是，在分支点修改神经反应可能是可行的。
The preterminal branching pattern of nerve fibers from the chorda tympani nerve was examined in the tongues of rats using a normal silver stain. The lingual branch of the trigeminal nerve was sectioned unilaterally proximal to where it is joined by the chorda tympani and these fibers were allowed to degenerate from eight to ten days prior to sacrifice of the animals. Termination of the chorda tympani fibers in the anterior tongue was found to be limited to the taste bud region of the fungiform papillae. The control side of the tongue showed ubiquitous fiber terminations in the basal layers of the common epithelium of the filiform papillae as well as in the lateral walls of the fungiform papillae. These fibers were assumed to be of trigeminal origin. Seventy‐nine percent of the fungiform papillae on the experimental side of the tongue received fibers from a branched nerve bundle. Branch points within the nerve bundles were located deep within the tongue 300–500 μ below the taste bud in 43% of the papillae, at the base of 36% of the fungiform papillae about 125 μ below the taste bud, and within the papilla.These data corroborate electrophysiological observations that single chorda tympani fibers receive input from more than one taste bud. Lateral inhibition observed among adjacent taste buds has been postulated to result from interaction of fiber inputs at branch points in the afferent fiber. From a theoretical consideration of the morphology of chorda tympani nerve fibers it is concluded that modification of the neural response may be feasible at branch points.