Disruption of hippocampal connectivity in children and adolescents with schizophrenia -: A voxel-based diffusion tensor imaging study
Disruption of hippocampal connectivity in children and adolescents with schizophrenia -: A voxel-based diffusion tensor imaging study
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DOI：
10.1016/j.schres.2006.09.032
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发表时间：
2007-02-01
影响因子：
4.5
通讯作者：
Lim, Kelvin O.
中科院分区：
文献类型：
--
作者：
White, Tonya;Kendi, Ayse Tuba Karagulle;Lim, Kelvin O.
一种将精神分裂症相关症状的多样性统一起来的假说涉及大脑区域之间连接的中断。由于白质在大脑区域之间提供快速有效的沟通，本研究旨在评估儿童和青少年精神分裂症患者白质通路的早期中断。材料和方法：获取14例精神分裂症儿童和青少年、1例分裂情感性障碍和15例年龄和性别匹配的对照组的弥散张量图像。在3t Siemens Trio扫描仪上采集12个方向的DTI图像。将图像转换为分数各向异性和平均扩散率图，并使用SPM2进行分组分析。结果：儿童和青少年精神分裂症患者在左后海马区FA显著减少，AD显著增加（p < 0.001， Bonferroni在聚类水平上进行校正）。当智商作为协变量在分析中使用时，这些扩散差异没有统计学意义。讨论：这些发现表明，海马体白质异常出现在精神分裂症发展的早期。当智商作为协变量使用时，缺乏显著差异表明该海马区域与精神分裂症相关的认知变化有关。(c) 2006 Elsevier B.V.版权所有
Introduction: One hypothesis that unifies the diversity of symptoms associated with schizophrenia involves the disruption of connectivity between brain regions. As white matter provides rapid and efficient communication between brain regions, this study was initiated to assess the early disruption of white matter pathways in children and adolescent with schizophrenia.Materials and methods: Diffusion tensor images were acquired on 14 children and adolescents with schizophrenia, one subject with schizoaffective disorder, and 15 age and gender matched controls. The DTI images were acquired in twelve directions on a 3 T Siemens Trio scanner. The images were transformed into fractional anisotropy and mean diffusivity maps and a group analysis was performed using SPM2.Results: Children and adolescent patients with schizophrenia demonstrated a significant decrease in FA and associated increase in AD in the left posterior hippocampus (p < 0.001, Bonferroni corrected on the cluster-level). These diffusion differences were not statistically significant when IQ was used as a covariate in the analysis.Discussion: These findings suggest hippocampal white matter abnormalities that present early in the development of schizophrenia. The lack of significant differences when IQ is used as a covariate suggests that this hippocampal region is associated with cognitive changes associated with schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.