Distribution of granulocytopoietic committed stem cells in mice with tumor induced neutrophilia.
Distribution of granulocytopoietic committed stem cells in mice with tumor induced neutrophilia.
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肿瘤诱导的中性粒细胞增多症小鼠中粒细胞生成定向干细胞的分布。
DOI：
10.4049/jimmunol.135.6.4266
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发表时间：
1980
影响因子：
2.6
通讯作者：
D. Dale
中科院分区：
文献类型：
--
作者：
M. Lee;A. Sperlin;D. Dale
研究了粒细胞生成定向干细胞（CFUc）在荷粒细胞增多症诱导肿瘤小鼠骨骼中的分布。估计每只小鼠的CFUc总数并与对照小鼠进行比较。在中轴骨骼（椎骨、颅骨、尾部）和外周骨骼（桡骨和尺骨）中骨髓发育的新区域中，CFUc的发生率增加，而中央无骨长骨（肱骨、股骨和胫骨）CFUc无变化。该研究表明，荷瘤小鼠中CFUc的总数增加，额外的数据支持先前的观察结果，并且该动物模型中的粒细胞增多症是由于细胞产生增加。该研究还表明，应谨慎解释基于单个长骨CFUc测定的粒细胞产生的CFUc总数的推断。
The skeletal distribution of granulocytopoietic committed stem cells (CFUc) was studied in mice bearing a granulocytosis inducing tumor. The total number of CFUc per mouse was estimated and compared with control mice. In both the axial skeleton (vertebrae, skull, tail) and new areas of marrow development in the peripheral skeleton (radii and ulnae), there was an increased incidence of CFUc, while central appendicular long bones (humeri, femora and tibias) CFUc were unchanged. The study indicated that the total number of CFUc in tumor bearing mice increased, additional data supporting the previous observation and the granulocytosis in this animal model is due to an increase in cell production. The study also indicated that inferences about total CFUc numbers of granulocyte production based on CFUc assay from a single long bone should be interpreted with caution.