Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
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用索宾尼尔（一种醛糖还原酶抑制剂）预防半乳糖白内障：光学显微镜研究。
DOI：
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发表时间：
1982
影响因子：
4.4
通讯作者：
J. Kinoshita
中科院分区：
文献类型：
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作者：
M. Datiles;H. Fukui;T. Kuwabara;J. Kinoshita
通过检眼镜、裂隙灯生物显微镜和使用甲基丙烯酸酯塑料包埋的光学显微镜研究了半乳糖血症大鼠的白内障形成。未经治疗的大鼠在 14 天时出现核性白内障，在 21 天时出现成熟性白内障。然而，用醛糖还原酶抑制剂索宾尼尔治疗的大鼠在长达 8 个月的 50% 半乳糖喂养中没有出现任何白内障变化，并且无法与正常对照组区分开来。这强烈表明醛糖还原酶是糖性白内障形成的常见因素。
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using plastic embedding with methacrylate. Untreated rats developed nuclear cataracts by 14 days and mature cataracts by 21 days. However, rats treated with the aldose reductase inhibitor sorbinil did not develop any cataractous change for up to 8 months of 50% galactose feeding and could not be distinguished from normal controls. This strongly suggests that aldose reductase is the common factor involved in the formation of sugar cataracts.