Mitotic spindle rotation and mode of cell division in the developing telencephalon
Mitotic spindle rotation and mode of cell division in the developing telencephalon
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DOI：
10.1073/pnas.0437969100
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发表时间：
2003-03-04
影响因子：
11.1
通讯作者：
Rakic, P
中科院分区：
文献类型：
--
作者：
Haydar, TF;Ang, E;Rakic, P
前脑增殖区神经干细胞的分裂方式通过调节神经元和神经胶质细胞的数量和多样性，深刻地影响新皮质的生长。胚胎小鼠皮质的长期延时多光子显微镜揭示了干细胞分裂前有丝分裂纺锤体复杂的三维旋转和振荡的新细节。重要的是，纺锤体运动的持续时间和幅度预测并确定了有丝分裂的最终模式。这些技术的进步为神经干细胞分裂的动力学提供了戏剧性的数据和见解，阐明了纺锤体旋转参与了卵裂面和神经干细胞分裂模式的选择，这两个因素共同决定了哺乳动物新皮质的大小。
The mode of neural stem cell division in the forebrain proliferative zones profoundly influences neocortical growth by regulating the number and diversity of neurons and glia. Long-term time-lapse multiphoton microscopy of embryonic mouse cortex reveals new details of the complex three-dimensional rotation and oscillation of the mitotic spindle before stem cell division. Importantly, the duration and amplitude of spindle movement predicts and specifies the eventual mode of mitotic division. These technological advances have provided dramatic data and insights into the kinetics of neural stem cell division by elucidating the involvement of spindle rotation in selection of the cleavage plane and the mode of neural stem cell division that together determine the size of the mammalian neocortex.